Gastro-oesophageal reflux disease in 'difficult-to-control' asthma: prevalence and response to treatment with acid suppressive therapy

Alimentary Pharmacology & Therapeutics
C H WongK L Goh

Abstract

The causal association between gastro-oesophageal reflux disease (GERD) and difficult-to-control asthma is unclear. To determine the prevalence of GERD and response to proton pump inhibitor therapy in patients with difficult-to-control asthma. Consecutive patients with difficult-to-control asthma as defined by persistent and recurrent symptoms despite on optimal asthmatic medications were recruited for the study. GERD was diagnosed by symptoms, gastroscopy and 24-h oesophageal pH monitoring. All patients were prescribed a course of lansoprazole 30 mg daily for 8 weeks. Improvement to treatment was assessed by a change in pulmonary symptom score and also by patient's subjective assessment of improvement. Seventeen of 30 (56.7%) patients with difficult-to-control asthma were diagnosed with GERD. Pulmonary symptom score improved significantly only in patients with GERD (35.0 to 21.0; P = 0.002). Twelve of 16 (75%) patients with GERD reported an improvement in asthma symptoms; 1 of 11 (9.1%) without GERD reported mild symptom improvement. There was no significant change in peak expiratory flow rate and forced expiratory volume. More than half of patients with difficult-to-control asthma were diagnosed with GERD. In these patients t...Continue Reading

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Citations

Sep 17, 2010·BMC Pulmonary Medicine·Lakmali D AmarasiriChanna D Ranasinha
Jan 24, 2014·Scientifica·Fulvio Braido
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Jul 7, 2016·Nature Reviews. Gastroenterology & Hepatology·Lesley A HoughtonJaclyn A Smith

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