PMID: 9534675Apr 16, 1998Paper

Gastro-oesophageal reflux in infants under 6 months with cystic fibrosis

Archives of Disease in Childhood
R G HeineA G Catto-Smith

Abstract

To establish the incidence of pathological gastro-oesophageal reflux (GOR) in newly diagnosed infants with cystic fibrosis and to identify clinical predictors of increased reflux. 26 infants with cystic fibrosis less than 6 months of age (14 male, 12 female; mean (SEM) age 2.1 (0.21) months, range 0.8 to 5.6 months) underwent prolonged oesophageal pH monitoring (mean duration 27.1 (0.49) hours; range 21.3 to 30.2 hours). Reflux symptoms, anthropometric variables, pancreatic status, meconium ileus, genotype, and chest x ray findings were correlated with pH monitoring data. Five infants (19.2%) had an abnormal fractional reflux time of greater than 10%, seven (26.9%) of 5-10%, and 14 (53.8%) of below 5%. Infants who presented with frequent vomiting had a significantly higher fractional reflux time than infants who had infrequent or no vomiting. There was no significant association between abnormal chest x rays and pathological GOR. Sex, genotype, nutritional status, meconium ileus, and pancreatic enzyme supplementation were not significantly associated with pathological GOR. About one in five newly diagnosed infants with cystic fibrosis had pathological GOR. Pathologically increased reflux was present before radiological lung dis...Continue Reading

References

Mar 3, 1979·Lancet·J R CrossleyP A Smith
Jan 1, 1992·Journal of Pediatric Gastroenterology and Nutrition·H J HeacockM Page
Nov 1, 1991·Archives of Disease in Childhood·A Malfroot, I Dab
May 1, 1991·Scandinavian Journal of Gastroenterology·P M GustafssonL Tibbling
May 1, 1991·Archives of Disease in Childhood·S CucchiaraG de Ritis
Jan 1, 1988·Scandinavian Journal of Gastroenterology. Supplement·I Dab, A Malfroot
Nov 1, 1987·Acta paediatrica Scandinavica·J FeigelsonY Pecau
Jan 1, 1985·American Journal of Surgery·C D VinocurW H Weintraub
Feb 1, 1985·The Journal of Pediatrics·R B ScottD G Gall
Apr 1, 1982·The Journal of Pediatrics·D W BendigG M Barrison
Feb 1, 1980·The Journal of Clinical Investigation·J DentD J Petrie
Aug 1, 1995·Archives of Disease in Childhood·R G HeineA G Catto-Smith
Aug 9, 1995·JAMA : the Journal of the American Medical Association·W H ChowJ F Fraumeni
Nov 1, 1993·The American Journal of Gastroenterology·E HassallL T Wong
Jan 1, 1993·The Journal of Pediatrics·S C FitzSimmons
Feb 13, 1997·The New England Journal of Medicine·R C Stern
Feb 1, 1997·Archives of Disease in Childhood·B M ButtonA Olinsky

❮ Previous
Next ❯

Citations

Jan 5, 2002·Early Human Development·S Koletzko, D Reinhardt
Apr 5, 2003·Best Practice & Research. Clinical Gastroenterology·Reuben Jackson, Paul B Pencharz
Oct 7, 2004·Journal of Cystic Fibrosis : Official Journal of the European Cystic Fibrosis Society·M SinaasappelG Döring
Apr 23, 2004·Archives of Disease in Childhood·B M ButtonA Olinsky
Sep 24, 2002·Archives of Disease in Childhood·G M NixonClaire Wainwright
Aug 1, 2002·Thorax·I M Balfour-Lynn, J S Elborn
Apr 9, 2011·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Solange Abdulnour-NakhoulNazih L Nakhoul
Feb 19, 2011·American Journal of Respiratory and Critical Care Medicine·Malena Cohen-CymberknohEitan Kerem
Aug 11, 2000·Paediatric Drugs·J M Littlewood, S P Wolfe
Mar 9, 2011·Current Gastroenterology Reports·Hubert P J van der DoefRoderick H J Houwen
Jan 19, 2016·Journal of Cystic Fibrosis : Official Journal of the European Cystic Fibrosis Society·Bruno HauserYvan Vandenplas
Mar 3, 2011·Pediatric Pulmonology·Patrick StaflerAndrew Bush
Jan 14, 2012·Pediatric Pulmonology·Michael DoumitYvonne Belessis
Apr 24, 2018·The Cochrane Database of Systematic Reviews·Diana A FreitasKarla Mpp Mendonça
May 17, 2018·Journal of Paediatrics and Child Health·Rishi BoliaMark R Oliver
Mar 11, 2015·The Cochrane Database of Systematic Reviews·Diana A FreitasKarla M P P Mendonça
Feb 5, 2003·Pediatric Pulmonology·Brenda M ButtonIan Story
Nov 17, 2005·Pediatric Pulmonology·James M LittlewoodSteven P Conway
Jul 7, 2016·Nature Reviews. Gastroenterology & Hepatology·Lesley A HoughtonJaclyn A Smith
May 28, 2019·Minerva pediatrica·Annarita BongiovanniSalvatore Leonardi
Jul 17, 2004·Pediatric and Developmental Pathology : the Official Journal of the Society for Pediatric Pathology and the Paediatric Pathology Society·Beverly Barrett Dahms
Jun 1, 1999·Journal of Genetic Counseling·T Brown, E L Schwind
Sep 16, 2004·Advances in Neonatal Care : Official Journal of the National Association of Neonatal Nurses·Shawna M Henry
Nov 18, 2020·European Journal of Pediatric Surgery : Official Journal of Austrian Association of Pediatric Surgery ... [et Al] = Zeitschrift Für Kinderchirurgie·Jessica NgPaul Charlesworth
Jan 15, 2000·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·H AnthonyP Phelan

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.