Abstract
Tourette syndrome (TS) is a chronic neuropsychiatric disorder. Its clinical manifestations are involuntary and recurrent muscle twitch, resulting in motor twitch and occurrence twitch. Traditional Chinese medicine has obvious advantages in treating TS. The aim of this study was to investigate the effects and mechanism of gastrodin on 1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane (DOI)-induced TS in rats. TS model was induced by DOI. Behaviors in TS rats were detected. The striatum, serum inflammatory factors interleukin-6, interleukin-1β, and tumor necrosis factor-a were detected by enzyme-linked immunosorbent assay. Western blot technique was used to detect the expressions of TLR/NF-κB and TLR/MAPK signaling pathways in the striatum. Gastrodin can significantly improve behavioral changes of TS rats induced by DOI, reduce inflammatory factors in serum and striatum in TS rats, and inhibit activation of TLR/NF-κB and TLR/MAPK signaling in striatum in TS rats. Gastrodin can significantly relieve the TS induced by DOI in rats. Its mechanism is related to the inhibition of striatal TLR/NF-κB and TLR/MAPK signaling activation.
References
Apr 13, 2010·Biomarkers in Medicine·Douglas Galasko, Thomas J Montine
Apr 20, 2010·Carcinogenesis·Li LiuQi B Mei
Jun 30, 2011·Gastroenterology·Romina FiorottoMario Strazzabosco
Sep 7, 2013·Journal of Pineal Research·Ze-Ping HuYuan Wang
Mar 25, 2014·Immunity·Yanbo ZhangHongyan Wang
Sep 10, 2014·Clinical Pediatrics·Debra L BylerCheston Berlin
Sep 23, 2014·International Immunopharmacology·Li CuiXiao Bin Jia
Dec 6, 2014·Movement Disorders : Official Journal of the Movement Disorder Society·Lauren E SchrockUNKNOWN Tourette Syndrome Association International Deep Brain Stimulation (DBS) Database and Registry Study Group
Dec 10, 2014·Movement Disorders : Official Journal of the Movement Disorder Society·Jeremiah M ScharfYoav Ben-Shlomo
Jan 7, 2015·Proceedings of the National Academy of Sciences of the United States of America·Meiyu XuChristopher Pittenger
Feb 1, 2015·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·Liucheng LiJian Gao
Dec 31, 2015·Congenital Anomalies·Tsukasa IshiguroYoshihiro Fukui
Feb 16, 2016·Progress in Neuro-psychopharmacology & Biological Psychiatry·Brent M KiousDavid R Shprecher
Aug 6, 2016·Journal of Psychiatric Research·Mohamed AbdulkadirAndrea Dietrich
Nov 4, 2016·European Child & Adolescent Psychiatry·Yuan-Yuan LuChih-Chia Huang
Mar 21, 2017·Pulmonary Pharmacology & Therapeutics·Hannes BucherDaniel Peter