Abstract
Hepatic ischemia-reperfusion (IR) injury remains the major cause of liver damage post-liver surgery or transplantation. Diminishing oxidative stress and inflammatory responses is a powerful channel to reduce the rate of morbidity and mortality. Gastrodin (GSTD), a bioactive compound extracted from the traditional Chinese herbal agent with a long history of clinical application in nervous system diseases, is suggested to possess anti-oxidative effects on liver diseases, such as nonalcoholic fatty liver disease. However, the therapeutic potential of GSTD in liver IR injury remains unclear. In this paper, we performed surgery to set up the 70% hepatic IR injury models in mice after a three-day pretreatment of GSTD. We found the administration of GSTD reduced liver damage, which correlated with lower histological Suzuki's score, lower serum alanine transaminase (AST) and alanine transaminase (ALT) levels, less oxidative stress, and cell apoptosis in a dose-responsive manner, as compared to the parallel control. Meanwhile, we observed a great induction of heme oxygenase-1 (HO-1) and an activation of the p38 mitogen-activated protein kinases/nuclear factor erythroid 2-related factor 2 (p38MAPK/Nrf2) pathway in response to the GSTD pr...Continue Reading
References
Dec 1, 1991·Transplantation·S SuzukiY Fujise
Oct 6, 1997·Proceedings of the National Academy of Sciences of the United States of America·K D Poss, S Tonegawa
Feb 16, 2002·Methods : a Companion to Methods in Enzymology·K J Livak, T D Schmittgen
Mar 5, 2002·Nature Medicine·Tzong-Shyuan Lee, Lee-Young Chau
Nov 26, 2002·The Journal of Biological Chemistry·Truyen NguyenCecil B Pickett
Mar 26, 2003·Genes to Cells : Devoted to Molecular & Cellular Mechanisms·Ken ItohMasayuki Yamamoto
Nov 9, 2004·Nature·Trude H FloAlan Aderem
Dec 9, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Fabio Re, Jack L Strominger
Jul 6, 2005·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Xiu-Da ShenJerzy W Kupiec-Weglinski
Sep 20, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Sei-ichiro TsuchihashiJerzy W Kupiec-Weglinski
Feb 15, 2008·Journal of Biochemical and Molecular Toxicology·Patrick L ApopaQiang Ma
Apr 29, 2009·The Journal of Experimental Medicine·Sotiria TzimaGeorge Kollias
Aug 12, 2009·PloS One·Zheng SunDonna D Zhang
Mar 12, 2010·World Journal of Gastroenterology : WJG·Zhong ZengYu-Jun Zhang
Oct 6, 2010·The Journal of Clinical Investigation·Amandine ViauFabiola Terzi
Mar 31, 2012·Transplantation Reviews·Hartmut Jaeschke, Benjamin L Woolbright
May 4, 2012·World Journal of Gastroenterology : WJG·Zhong ZengMing-Qing Chen
Mar 28, 2013·Evidence-based Complementary and Alternative Medicine : ECAM·Hemant KumarDong-Kug Choi
Apr 5, 2013·World Journal of Gastroenterology : WJG·Gourab DattaBrian R Davidson
Jul 19, 2013·PloS One·Kathrin EllerIgor Theurl
Oct 1, 2011·Journal of Traditional and Complementary Medicine·Pei-Ju Chen, Lee-Yan Sheen
Jun 17, 2014·Neurochemistry International·Genling JiangQinglin Li
Dec 5, 2015·Phytotherapy Research : PTR·Li-Li QuWei-Jia Kong
Apr 22, 2016·Cellular and Molecular Life Sciences : CMLS·Agnieszka LobodaJozef Dulak
Jul 6, 2016·Journal of Ethnopharmacology·Hong-Dan ZhanTing-Liang Jiang
Feb 20, 2018·Frontiers in Pharmacology·Yuan LiuGuomin Si
May 2, 2018·Biological & Pharmaceutical Bulletin·Yong ZhangWei-Jia Kong
Aug 28, 2018·Oxidative Medicine and Cellular Longevity·Meifang ZhuBo Yi
Aug 30, 2018·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·Hongbin ZhangZhong Zeng