PMID: 9176815Apr 1, 1997Paper

Gastroenteropancreatic effects of xenin in the dog

The Journal of Peptide Research : Official Journal of the American Peptide Society
G E FeurleG Hamscher

Abstract

Xenin is a 25 amino acid peptide detected in the gastric mucosa of various mammals. It has since been found in low concentrations in other tissues. Xenin plasma concentrations increase after meals. The present study reports some gastroenteropancreatic effects of this peptide in the dog. Intravenous infusion of 64 pmol/kg min synthetic xenin significantly inhibited pentagastrin-stimulated gastric acid secretion and stimulated exocrine pancreatic secretion of volume and protein. Further, intravenous infusion of xenin in a dose of 1.0 pmol/kg min stimulated jejunal motility in the anaesthetized dog. An intravenous infusion of 32 pmol/kg min xenin raised plasma concentrations of pancreatic polypeptide, vasoactive intestinal polypeptide, insulin and glucagon. The present experiments therefore indicate manifold bioactive properties of intravenously infused xenin in the dog, with jejunal motility the most sensitive target. Conclusions as to the physiological role of xenin cannot be drawn from the present experiments. The release of other hormonal peptides indicates a complex action of xenin.

References

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Citations

Feb 16, 2007·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·Y KamiyamaH Kuwano
Dec 21, 2013·American Journal of Physiology. Gastrointestinal and Liver Physiology·Sara ChowdhuryBurton M Wice
Apr 13, 2019·American Journal of Physiology. Gastrointestinal and Liver Physiology·Atsukazu KuwaharaYoshinori Marunaka
Jul 28, 2001·Diabetes Technology & Therapeutics·R PerfettiS Busselen
Apr 28, 2010·The Journal of Biological Chemistry·Burton M WiceKenneth S Polonsky
Feb 13, 2014·The Journal of Endocrinology·Christine M A MartinNigel Irwin
Oct 23, 2012·American Journal of Physiology. Gastrointestinal and Liver Physiology·Sheng ZhangBurton M Wice
Apr 11, 2018·Diabetes/metabolism Research and Reviews·Sarah L CraigNigel Irwin
Aug 26, 1998·The Journal of Peptide Research : Official Journal of the American Peptide Society·B StoschusG E Feurle
Dec 2, 2000·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·M AnlaufG E Feurle
Jul 5, 2001·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·G E FeurleG Hamscher
Feb 19, 2021·Physiological Reports·Yuko KuwaharaAtsukazu Kuwahara
Apr 4, 2021·Nutrients·Van B LuFrank Reimann
Apr 9, 1998·Peptides·G E Feurle
Jul 23, 2003·Regulatory Peptides·Ramona A SilvestreJosé Marco
Oct 31, 2002·Gastroenterology·Gerhard E FeurleEberhard Weihe

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