PMID: 11321390Apr 26, 2001Paper

Gastroesophageal endoscopic findings and gastrointestinal symptoms in preterm neonates with and without perinatal indomethacin exposure

Journal of Pediatric Gastroenterology and Nutrition
R OjalaO Tammela

Abstract

The aim of this study was to investigate whether perinatal indomethacin treatment has effects on the development of esophageal and gastric lesions in preterm infants and to evaluate other potential etiologic factors behind these lesions. Sixty-nine infants were born at less than 33 weeks' gestation. Forty-five of these infants underwent treatment with perinatal indomethacin (study group) and 24 did not (control group). All underwent upper gastrointestinal tract endoscopy and biopsy during the neonatal period. The correlation between gastrointestinal symptoms, abnormal endoscopic findings, and the factors correlating with the development of esophageal and gastric mucosal lesions was evaluated. Abnormal endoscopic findings were equally common in the study group (77.8%) and in controls (83.3%). There was no dependence between gastrointestinal symptoms and endoscopic findings because only 15 infants (21.7%) were symptomatic before endoscopy. The interval between endoscopy and the last perinatal indomethacin dose correlated significantly with abnormal esophageal findings and gastric mucosal lesions. Shorter duration of enteral feeding before endoscopy correlated with greater risk of abnormal esophageal findings. Older gestational ag...Continue Reading

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Citations

Nov 6, 2012·Arab Journal of Gastroenterology : the Official Publication of the Pan-Arab Association of Gastroenterology·Rania H TomerakAmira H Mahmoud
Apr 20, 2005·Neonatal Network : NN·Davita Hammer
Mar 30, 2005·Journal of Pediatric Gastroenterology and Nutrition·Christophe DupontPierre-Henri Benhamou
Jan 17, 2009·American Journal of Physiology. Gastrointestinal and Liver Physiology·Tania MarchbankRaymond J Playford

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