PMID: 36677Jul 1, 1979

Gastroesophageal reflux and pulmonary aspiration: incidence, functional abnormality, and results of surgical therapy

Surgery
C A PellegriniD B Skinner

Abstract

The incidence of aspiration, the causative esophageal pathophysiology, and the results of surgical therapy were evaluated in 100 patients with abnormal gastroesophageal reflux documented by 24-hour esophageal pH monitoring. Based on historical evidence, 48 patients were suspected to be aspirators. Eight patients had documented episodes of aspiration (drop on esophagela pH, followed by acid taste in mouth and onset of cough or wheezing spell) during the monitoring period. Nine patients were considered to be potential aspirators because they presented oral acid regurgitation without development of pulmonary symptoms. In five patients a primary respiratory disorder (PRD) induced gastroesophageal reflux. The remaining 78 patients had abnormal reflux without aspiartion or regurgitation. Aspirators had a 75% incidence of esophageal motor abnormality on manometry, and the clearance of refluxed acid was significantly delayed in the supine position. A history of heartburn and endoscopic evidence of esophagitis were present in only half of the patients who were documented aspirators. Potential aspirators were spared from aspiration by rapid esophageal clearance of refluxed acid unaffected by changes in body position. Patients with a PRD ...Continue Reading

Citations

Jan 9, 1998·The American Journal of Medicine·S J Sontag
Jan 9, 1998·The American Journal of Medicine·N R Olson
Jan 9, 1998·The American Journal of Medicine·R A HinderK R DeVault
Jan 9, 1998·The American Journal of Medicine·A J Ing
May 10, 2000·Forensic Science International : Synergy·K IwadateH Hasekura
Jan 16, 1999·Gastroenterology Clinics of North America·M A Young, J C Reynolds
Nov 22, 1997·Journal of Clinical Epidemiology·T Q Miller
Nov 1, 1985·Annals of Surgery·D B Skinner
Jul 1, 1992·Gut·S J SontagL Brand
Feb 1, 1981·Thorax·R J GoodallJ G Temple
Aug 1, 1985·Thorax·N M WilsonM Silverman
Jul 9, 2011·Pulmonary Medicine·Ahmed FahimSimon P Hart
Dec 20, 2008·American Journal of Respiratory and Critical Care Medicine·Edoardo SavarinoMassimo Ghio
Aug 6, 2011·The Journal of Surgical Research·P Marco FisichellaRichard L Gamelli
Jun 1, 1992·Diseases of the Colon and Rectum·W C Cirocco, J C Reilly

Related Concepts

Coughing
Peptic Esophagitis
Gastric Juice
Gastroesophageal Reflux Disease
Hydrogen-Ion Concentration
Tonometry
Peristalsis
Aspiration Pneumonia
Respiratory Tract Diseases

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