Gastroesophageal Reflux Burden, Even in Children That Aspirate, Does Not Increase Pediatric Hospitalization

Journal of Pediatric Gastroenterology and Nutrition
Daniel R DuncanRachel Rosen

Abstract

Gastroesophageal reflux is common but remains a controversial disease to diagnose and treat and little is known about the role of reflux testing in predicting clinical outcomes, particularly in children at risk for extraesophageal reflux complications. The aim of this study was to determine if rates of hospitalization were affected by reflux burden even after adjusting for aspiration risk. We prospectively recruited, between 2009 and 2014, a cohort of pediatric patients with suspected extraesophageal reflux disease who were referred for reflux testing and underwent both multichannel intraluminal impedance with pH (pH-MII) and modified barium swallow studies. A subset of patients also underwent bronchoalveolar lavage with pepsin analysis. We determined their rates of hospitalization for a minimum of 1 year following pH-MII testing. We prospectively enrolled 116 pediatric patients who presented for care at Boston Children's Hospital and underwent both pH-MII and modified barium swallow studies. There was no statistically significant relationship between reflux burden measured by pH-MII or bronchoalveolar pepsin and total number of admissions or number of admission nights even after adjusting for aspiration status (P > 0.2). There...Continue Reading

References

Apr 1, 1992·Journal of Pediatric Gastroenterology and Nutrition·S R Orenstein
Jan 13, 2006·PLoS Medicine·Joseph P Mizgerd
Feb 14, 2006·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Rachel RosenSamuel Nurko
Nov 3, 2006·Pediatrics·Michael S LasserRandall S Burd
Jan 22, 2008·Journal of Pediatric Surgery·Steven L LeePhilip I Haigh
Mar 4, 2009·Pediatrics·Angelo CampanozziAnnamaria Staiano
Jun 30, 2009·Journal of Pediatric Gastroenterology and Nutrition·Yvan VandenplasHendrik Reynaert
Feb 2, 2010·Journal of Pediatric Gastroenterology and Nutrition·Rachel RosenSamuel Nurko
Mar 17, 2011·Journal of Pediatric Gastroenterology and Nutrition·Rachel RosenSamuel Nurko
Feb 9, 2012·Diseases of the Esophagus : Official Journal of the International Society for Diseases of the Esophagus·T Hershcovici, R Fass
Jun 20, 2012·Journal of Pediatric Gastroenterology and Nutrition·Tobias G WenzlUNKNOWN ESPGHAN EURO-PIG Working Group
Dec 12, 2012·The Journal of Pediatrics·Rachel J van der PolMerit M Tabbers
May 1, 2013·Pediatrics·Jenifer R LightdaleUNKNOWN Section on Gastroenterology, Hepatology, and Nutrition
Aug 8, 2013·JAMA Pediatrics·Shawn J Rangel
Aug 8, 2013·JAMA Pediatrics·Douglas C BarnhartRajendu Srivastava
Aug 15, 2013·Journal of Pediatric Gastroenterology and Nutrition·Rachel RosenSamuel Nurko
Sep 3, 2013·Current Opinion in Pediatrics·David ForbesMadhur Ravikumara
Oct 12, 2013·The Laryngoscope·Robert F Yellon, Alka Goyal
Nov 28, 2013·JAMA Pediatrics·Rachel Rosen
May 9, 2014·Chest·Augustine LeeUNKNOWN United States Critical Illness and Injury Trials Group
Oct 2, 2014·Journal of Pediatric Gastroenterology and Nutrition·Rachel J van der PolMichiel P van Wijk

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Citations

Oct 17, 2018·JAMA Otolaryngology-- Head & Neck Surgery·Daniel R DuncanRachel L Rosen
Nov 28, 2019·JAMA Otolaryngology-- Head & Neck Surgery·Claire M Lawlor, Sukgi Choi
May 28, 2019·Current Treatment Options in Pediatrics·Lusine AmbartsumyanRachel Rosen

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Methods Mentioned

BETA
bronchoalveolar lavage
biopsy

Software Mentioned

NASPGHAN
SAS

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