Gastroesophageal Reflux Disease in Obese Patients

Journal of Laparoendoscopic & Advanced Surgical Techniques. Part a
Antono C ValeziMarco G Patti

Abstract

Gastroesophageal reflux disease (GERD) and obesity coexist in many patients in the Western population. The association is not coincidental, since GERD pathophysiology is, in part, linked to obesity. Visceral adipose tissue secretes hormones, which increase the risk of GERD. Obesity increases esophageal motor disorders and higher number of transient lower esophageal sphincter relaxations. Central obesity increases abdominal-thoracic pressure gradient and disrupts the gastroesophageal junction by inducing hiatal hernia formation. Obese patients benefit from weight loss by diet to decrease GERD symptoms; however, Roux-en-Y gastric bypass surgery is associated with a higher weight loss and a decrease in GERD symptoms, and is considered the best way to treat both diseases at the same time.

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Citations

May 23, 2020·Expert Review of Gastroenterology & Hepatology·Francisco SchlottmannMarco G Patti
Sep 21, 2019·Journal of Laparoendoscopic & Advanced Surgical Techniques. Part a·Federico Cuenca-AbenteDiego Ferro
Apr 8, 2020·World Journal of Clinical Cases·Duolikun YashengKelimu Abudureyimu
Jan 15, 2021·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Leonardo de Mello Del GrandeM G Patti
Feb 23, 2020·Surgery for Obesity and Related Diseases : Official Journal of the American Society for Bariatric Surgery·Benjamin ClappAlan Tyroch
Oct 28, 2019·Journal of Voice : Official Journal of the Voice Foundation·Janaina Regina BossoLuiz Eduardo Naresse
Apr 10, 2021·Journal of Voice : Official Journal of the Voice Foundation·Janaina Regina BossoRegina Helena Garcia Martins
Aug 14, 2021·JGH Open : an Open Access Journal of Gastroenterology and Hepatology·Khean-Lee GohReuben Kong-Min Wong

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Methods Mentioned

BETA
hormone replacement
gastric bypass

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