Gastroesophageal reflux in asymptomatic obese subjects: An esophageal impedance-pH study

World Journal of Gastroenterology : WJG
Filiz AkyüzNurdan Gul

Abstract

To investigate the relationship between reflux and body mass index (BMI) in the asymptomatic obese population using the impedance-pH technique. Gastroesophageal reflux is frequent in the obese population. However, the relationship between acid reflux and BMI in asymptomatic obese people is unclear. Forty-six obese (BMI > 25 kg/m(2)) people were enrolled in this prospective study. We evaluated the demographic findings and 24-h impedance pH values of the whole group. Gas, acid (pH < 4), weak acid (pH = 4-7) and weak alkaline (pH ≥ 7) reflux parameters were analyzed. The mean age of patients was 49.47 ± 12.24 years, and half of them were men. The mean BMI was 30.64 ± 3.95 kg/m(2) (25.14-45.58 kg/m(2)). BMI of 23 was over 30 kg/m(2). Seventeen patients had a comorbidity (hypertension, diabetes mellitus, or ischemic heart disease). Endoscopic examination revealed esophagitis in 13 of the 28 subjects (10 Grade A, 3 Grade B). The subjects were divided into two groups according to BMI (< 30 and > 30 kg/m(2)). Demographic and endoscopic findings, and impedance results were similar in these two groups. However, there was a positive correlation between BMI and total and supine pH < 4 episodes (P = 0.002, r = 0.414; P = 0.000, r = 0.542), ...Continue Reading

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Citations

Nov 1, 2016·Digestive Diseases and Sciences·Sang Pyo LeeChan Sup Shim
Oct 8, 2019·Journal of Neurogastroenterology and Motility·Sihui LinXiucai Fang
Nov 1, 2017·World Journal of Gastroenterology : WJG·Midori FujishiroTakashi Kadowaki
May 25, 2016·Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·W Timothy GarveyUNKNOWN Reviewers of the AACE/ACE Obesity Clinical Practice Guidelines
Jun 23, 2021·Expert Review of Gastroenterology & Hepatology·Jiarong LinZhijun Duan

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