Gastroesophageal reflux in patients with morbid obesity: a role of obstructive sleep apnea syndrome?

Obesity Surgery
J M SabatéB Coffin

Abstract

Obesity is a risk factor for gastroesophageal reflux disease (GERD) and for obstructive sleep apnea (OSA). Our aim was to evaluate in morbidly obese patients the prevalence of OSA and GERD and their possible relationship. Morbidly obese patients [body mass index (BMI) >40 or >35 kg/m(2) in association with comorbidities] selected for bariatric surgery were prospectively included. Every patient underwent a 24-h pH monitoring, esophageal manometry, and nocturnal polysomnographic recording. Sixty-eight patients [59 women and 9 men, age 39.1 +/- 11.1 years; BMI 46.5 +/- 6.4 kg/m(2) (mean +/- SD)] were included. Fifty-six percent of patients had an abnormal Demester score, 44% had abnormal time spent at pH <4, and 80.9% had OSA [apnea hypopnea index (AHI) >10] and 39.7% had both conditions. The lower esophageal sphincter (LES) pressure was lower in patients with GERD (11.6 +/- 3.4 vs 13.4 +/- 3.6 mm Hg, respectively; P = 0.039). There was a relationship between AHI and BMI (r = 0.337; P = 0.005). Patients with OSA were older (40.5 +/- 10.9 vs 33.5 +/- 10.4 years; P = 0.039). GERD tended to be more frequent in patients with OSA (49.1% vs 23.1%, respectively; P = 0.089). There was no significant relationship between pH-metric data and...Continue Reading

References

Jan 1, 1986·Journal of Clinical Gastroenterology·L F Johnson, T R DeMeester
Feb 1, 1984·The Journal of Pediatrics·A R SpitzerW W Fox
Aug 8, 1994·Archives of Internal Medicine·A N VgontzasA Kales
Jan 7, 2000·The European Respiratory Journal·T PenzelJ H Peter
Mar 4, 2000·BMJ : British Medical Journal·P LavieV Hoffstein
Mar 16, 2000·The American Journal of Medicine·A J IngA B Breslin
Sep 28, 2001·Archives of Surgery·S A WajedT R DeMeester
Jan 22, 2002·The Laryngoscope·B A SeniorM Benninger
Feb 5, 2002·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Shivakumar ChitturiJacob George
Jun 18, 2002·Chest·Arschang ValipourStephen G Spiro
Jul 23, 2002·Lancet·Atul Malhotra, David P White
Feb 26, 2004·Obesity Surgery·Terence O'Keeffe, Emma J Patterson
Sep 9, 2004·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Chad A MorseRonnie Fass
Nov 6, 2004·Alimentary Pharmacology & Therapeutics·W C OrrM Kryger
Sep 22, 2005·World Journal of Gastroenterology : WJG·Levent Ozturk, Zerrin Pelin
Feb 8, 2006·La Presse médicale·Jean-François BretagnePhilippe Barthélemy
Jun 2, 2006·The New England Journal of Medicine·Brian C JacobsonCarlos A Camargo

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Citations

Aug 17, 2010·Sleep & Breathing = Schlaf & Atmung·Kelly ShepherdPeter Eastwood
Aug 5, 2010·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·Edwin Seet, Frances Chung
Apr 6, 2013·Regional Anesthesia and Pain Medicine·Stavros G MemtsoudisMadhu Mazumdar
Jan 10, 2009·World Journal of Gastroenterology : WJG·Barry P McMahonHans Gregersen
Sep 17, 2013·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Cadman L LeggettPrasad G Iyer
Dec 4, 2010·Best Practice & Research. Clinical Gastroenterology·Sabine Roman, John E Pandolfino
Jan 19, 2012·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·S Hashimoto, E H Bel
Apr 24, 2012·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·Y-L XiaoM-H Chen
Aug 15, 2014·Clinical Otolaryngology : Official Journal of ENT-UK ; Official Journal of Netherlands Society for Oto-Rhino-Laryngology & Cervico-Facial Surgery·C-C WangR-S Jiang
Apr 5, 2013·The Journal of Asthma : Official Journal of the Association for the Care of Asthma·Mohamed EssalhiChristophe Delclaux
Aug 23, 2016·Medical Journal, Armed Forces India·B N B M Prasad
Oct 28, 2016·Annals of the New York Academy of Sciences·Jung Hwan Oh
Nov 2, 2013·Therapeutic Advances in Chronic Disease·Irene MartinucciSantino Marchi
Dec 22, 2014·Orvosi hetilap·Csilla Zita TurányiMárta Novák
Jul 23, 2014·Scandinavian Journal of Gastroenterology·Takahiro ZendaHidekuni Inadera
Nov 26, 2020·Digestive Diseases and Sciences·Yousef ElfanagelySteven F Moss
Sep 16, 2019·Revue des maladies respiratoires·A De JongS Jaber
Feb 19, 2020·Anaesthesia Critical Care & Pain Medicine·Audrey De JongSamir Jaber
May 22, 2010·Anesthesiology Clinics·Edwin Seet, Frances Chung

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