Gastroesophageal reflux induced by white wine: the role of acid clearance and "rereflux"

The American Journal of Gastroenterology
Christian PehlAlbrecht Pfeiffer

Abstract

White wine has been demonstrated to induce gastroesophageal reflux (GER) in healthy people and GER patients. This GER is characterized by reflux episodes of prolonged duration. Our aim was to explore the pathogenesis of the prolonged reflux duration. Twelve healthy volunteers received in a randomized order 300 ml of white wine and tap water together with a standardized meal. Esophageal pH and motility were continuously monitored by a glass pH electrode and a strain gauge manometry probe (four measuring points in the esophagus and one in the pharynx to register swallowing) for 90 min after ingestion. Blinded to the ingested beverage, we calculated the fraction of time esophageal pH was <4, the number of reflux episodes and their duration, the swallowing and contraction rate, the contraction amplitude, and the distribution of primary, secondary, simultaneous, and nonpropagated contractions. The motility analysis was separately performed for periods with and without GER. During GER, the time until occurrence of the first contraction, its type, the type of the contraction that raises pH to >4, and the number of peristaltic contractions necessary to raise pH to >4 were also determined. The percentage of GER episodes with simultaneou...Continue Reading

References

Oct 1, 1976·Annals of Surgery·T R DemeesterD B Skinner
Apr 1, 1978·Gut·S E Kaufman, M D Kaye
Jan 1, 1978·Scandinavian Journal of Gastroenterology·G Kjellén, L Tibbling
Feb 1, 1976·Oral Surgery, Oral Medicine, and Oral Pathology·D C AbelsonM Karmiol
Apr 1, 1992·Digestive Diseases and Sciences·A KeshavarzianM Durkin
Aug 1, 1990·Alcoholism, Clinical and Experimental Research·A KeshavarzianM Durkin
Jan 1, 1988·Gastroenterology·P J KahrilasW J Hogan
Mar 1, 1987·Gastroenterology·A KeshavarzianY Ferguson
Mar 8, 1974·Deutsche medizinische Wochenschrift·G A Martini, M Wienbeck
Jun 1, 1972·Journal of Applied Physiology·W J HoganD H Winship
Mar 1, 1971·Journal of Dental Research·S Martin, R M Pangborn
Jan 1, 1984·The Medical Clinics of North America·E J BurbigeC H Halsted
Feb 2, 1984·The New England Journal of Medicine·J F HelmB C Teeter
Dec 16, 1982·The New England Journal of Medicine·W J DoddsM S Egide
May 1, 1981·Digestive Diseases and Sciences·W C OrrL F Johnson
Feb 1, 1980·The Journal of Clinical Investigation·J DentD J Petrie
Jan 1, 1995·Gastroenterology·M N SchoemanR H Holloway
Sep 1, 1993·Annals of Surgery·R M BremnerT R DeMeester
Jan 1, 1993·Digestive Diseases and Sciences·C PehlH Kaess
Jun 1, 1996·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·R PenaginiR H Holloway
Jun 1, 1997·Digestive Diseases and Sciences·L GrandeC Pera
Mar 21, 1998·Digestive Diseases and Sciences·S S Shay, J E Richter
Jun 6, 1998·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·L GrossiL Marzio
Mar 16, 2000·The American Journal of Medicine·R H Holloway
Feb 24, 2001·Scandinavian Journal of Gastroenterology·C PehlA Pfeiffer
Feb 1, 1956·Journal of Dental Research·L H SCHNEYERR W GILMORE

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Citations

Mar 12, 2004·Journal of Gastroenterology and Hepatology·Kwong Ming FockJose Sollano
Sep 12, 2007·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Hugo BonattiRonald A Hinder

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