PMID: 8956182Nov 1, 1996Paper

Gastrointestinal absorption of insulinlike growth factor-I in neonatal pigs

Journal of Pediatric Gastroenterology and Nutrition
R J Xu, T Wang

Abstract

To determine if milk-borne insulinlike growth factor-I (IGF-I) is absorbed in neonatal piglets, recombinant human IGF-I was iodinated and then administered via an oral-gastric tube to newborn and 3-day-old piglets together with fluorescent isothiocyanate dextran (FITC-D70s, a macromolecular marker for assessment of gut closure). Results showed that total radioactivity and trichloroacetic acid (TCA)-precipitable radioactivity rose significantly in the plasma of both newborn and 3-day-old piglets 1 hour after oral-gastric administration of 125I-IGF-I, although the magnitude of increase was greater in newborns than in 3-day-old piglets. In contrast, significant absorption of FITC-D70s was observed only in newborn piglets but not in 3-day-old piglets. Chromatographic analysis revealed that 125I-IGF-I represented up to 20% of total plasma radioactivity in the newborns and up to 10% in the 3-day-old piglets. The 125I-IGF-I found in the plasma was mostly bound to IGF-binding proteins. These results indicate that milk-borne IGF-I can be absorbed in neonatal piglets and the absorption is independent of gut closure.

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Citations

May 5, 2000·Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology·W H Shen, R J Xu
Nov 26, 1998·Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology·J N Mubiru, R J Xu
Sep 29, 2007·Nutrition Journal·Janet W Rich-EdwardsA Lindsay Frazier
Jul 31, 2014·Reproduction : the Official Journal of the Society for the Study of Fertility·Meredith E CampCarol A Bagnell
May 27, 2010·Nutrition Research Reviews·Paul GuilloteauCornelia C Metges
Aug 22, 2002·Journal of Science and Medicine in Sport·J D BuckleyP B D Whyte
Mar 19, 2014·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Zuowei SongChengliang Gong
Mar 22, 2007·Nutrition in Clinical Practice : Official Publication of the American Society for Parenteral and Enteral Nutrition·Coryn E Commare, Kelly A Tappenden
Oct 19, 2017·Journal of Developmental Origins of Health and Disease·N TayJ P Buschdorf
Oct 24, 2002·Journal of Pediatric Gastroenterology and Nutrition·Anthony F PhilippsBohuslav Dvorák
Aug 15, 2000·Journal of Pediatric Gastroenterology and Nutrition·A F PhilippsO Koldovský
Apr 5, 2000·Journal of Pediatric Gastroenterology and Nutrition·W H Shen, R J Xu
Feb 28, 2002·Pediatric Research·Frank H BloomfieldJane E Harding
Oct 4, 2000·Physiological Reviews·J Pácha
Sep 14, 1999·The American Journal of Physiology·A N Alexander, H V Carey
Nov 12, 2003·The Journal of Pharmacology and Experimental Therapeutics·Xueying YanQiang Zhang
Jul 23, 2002·Journal of Applied Physiology·Antti MeroJuhani Leppäluoto

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