PMID: 9661317Jul 14, 1998Paper

Gastrointestinal allergy to food: a review

Journal of Diarrhoeal Diseases Research
T Ahmed, George J Fuchs

Abstract

Gastrointestinal food allergy still poses a challenge to the clinician because of its variable symptomatology and lack of reliable diagnostic tests. Its prevalence is estimated at 2 approximately 5%, higher in children than in older age-groups. Allergy to food usually diminishes with advancing age. Although a wide variety of foods can cause allergic reactions, cow's milk is the most common cause of food allergy in infants and young children. Depending upon the speed of onset of symptoms, immediate and delayed types of food allergy have been described. Gastrointestinal symptoms in food allergy have been explained by alterations in transport across the intestinal wall (increased secretory and/or decreased absorptive functions), increased permeability, and motility of the intestine. The exact pathogenesis of food allergy is still not clear. However, immediate type of food allergy is believed to be mediated by type I hypersensitivity reaction, involving mast cells and food-specific IgE antibodies. The diagnosis of food allergy is based upon a favorable response to an elimination diet and a response to a challenge with the suspected food. The condition is treated by eliminating the allergenic food from diet for as long as 9-12 month...Continue Reading

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