PMID: 20128070Feb 4, 2010Paper

Gastrointestinal and cardiovascular risk of non-selective NSAIDs and COX-2 inhibitors in elderly patients with knee osteoarthritis

Journal of the Medical Association of Thailand = Chotmaihet Thangphaet
Thana TurajaneThawee Songpatanasilp

Abstract

To evaluate the incidence and risk profiles for gastrointestinal (GI) events and cardiovascular (CV) events in elderly patients (aged > or =60 years) with knee osteoarthritis using tNSAIDs (traditional non-steroidal anti-inflammatory drugs) or coxibs users in patients with knee osteoarthritis aged > or =60 years. A hospital-based retrospective cohort study was applied. Data on prescription drug (NSAIDs, celecoxib, etoricoxib) was obtained from hospital database. Data on CV events and GI adverse events was obtained from the registry of the Cardiology Unit and Gastroesophagoscope Diagnosis Center, GI Center, Department of Internal medicine, Police General Hospital. Patients visiting the hospitals' outpatient clinics from June 2004 to June 2007 were included if they were aged > or =60 years and received at least one follow-up visit on the prescription of a tNSAIDNSAID or coxibs (etoricoxib or celecoxib). Patients with a history of gastrointestinal disease or heart disease were excluded. All patients were followed-up from their first visit to the date of their earliest event or to the end of the study period. The interested event was assumed to be attributed to the last prescription shown in the study period. A total 12,591 prescri...Continue Reading

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