Gastrointestinal and hepatic abnormalities in patients with confirmed COVID-19: A systematic review and meta-analysis.

Journal of Medical Virology
Ahmadreza ZarifianAzita Ganji

Abstract

Although not common, gastrointestinal and liver symptoms have reportedly been the initial presentation of coronavirus disease-2019 (COVID-19) in a large group of patients. Therefore, knowing the frequency and characteristics of these manifestations of COVID-19 is important for both clinicians and health policy makers. A systematic review and meta-analysis of the available data on the gastrointestinal and liver manifestations of patients with COVID-19 was performed. PubMed and Scopus databases and Google Scholar search engine were searched for published and unpublished preprint articles up to 10 April 2020. Original studies providing information on clinical digestive symptoms or biomarkers of liver function in patients with polymerase chain reaction confirmed diagnosis of COVID-19 were included. After quality appraisal, data were extracted. Prevalence data from individual studies were pooled using a random-effects model. Overall, 67 studies were included in this systematic review and meta-analysis, comprising a pooled population of 13 251 patients with confirmed COVID-19. The most common gastrointestinal symptoms were anorexia (10.2%, 95% confidence interval [CI] = 6.2%-16.4%), diarrhea (8.4%, 95% CI = 6.2%-11.2%), and nausea (5...Continue Reading

References

Oct 6, 1997·BMJ : British Medical Journal·M EggerC Minder
Feb 2, 2002·Journal of Health Services Research & Policy·Julian HigginsDouglas Altman
Mar 19, 2013·Research in Developmental Disabilities·Lonneke WeierinkRoslyn N Boyd
Jan 25, 2020·The New England Journal of Medicine·Na ZhuUNKNOWN China Novel Coronavirus Investigating and Research Team
Feb 7, 2020·Radiology·Fengxiang SongYuxin Shi
Feb 8, 2020·JAMA : the Journal of the American Medical Association·Dawei WangZhiyong Peng
Feb 23, 2020·The Lancet. Gastroenterology & Hepatology·Charleen YeoDanson Yeo
Feb 26, 2020·Journal of Digestive Diseases·Qin Yan GaoJing Yuan Fang
Feb 28, 2020·The Lancet Infectious Diseases·Heshui ShiChuansheng Zheng
Feb 29, 2020·The New England Journal of Medicine·Wei-Jie GuanUNKNOWN China Medical Treatment Expert Group for Covid-19
Feb 29, 2020·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Jian WuLanjuan Li
Mar 1, 2020·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Jiehao CaiMei Zeng
Mar 4, 2020·JAMA : the Journal of the American Medical Association·Barnaby Edward YoungUNKNOWN Singapore 2019 Novel Coronavirus Outbreak Research Team
Mar 13, 2020·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Dahai ZhaoRongbao Gao
Mar 17, 2020·The Journal of Infection·Jun ChenHongzhou Lu
Mar 17, 2020·International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases·Jing YangYongning Zhou
Mar 17, 2020·International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases·Fang LiuJun Zhang
Mar 17, 2020·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Pingzheng MoYongxi Zhang
Mar 18, 2020·Travel Medicine and Infectious Disease·Alfonso J Rodriguez-MoralesUNKNOWN Latin American Network of Coronavirus Disease 2019-COVID-19 Research (LANCOVID-19). Electronic address: https://www.lancovid
Mar 18, 2020·International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases·Tianmin XuYuan Xue
Mar 22, 2020·Journal of Medical Virology·Suxin WanRuishan Yang
Mar 25, 2020·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Shihua LuoHaibo Xu
Mar 27, 2020·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Yinxiaohe SunUNKNOWN National Centre for Infectious Diseases COVID-19 Outbreak Research Team
Mar 28, 2020·Journal of Gastroenterology and Hepatology·Sunny H WongJoseph Jy Sung
Mar 29, 2020·The Journal of Clinical Investigation·Guang ChenQin Ning
Mar 30, 2020·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Fengting YuFujie Zhang
Apr 8, 2020·Clinics and Research in Hepatology and Gastroenterology·Xiang-Yu LiHong-Gang Wang
Apr 8, 2020·Arab Journal of Gastroenterology : the Official Publication of the Pan-Arab Association of Gastroenterology·Sherief Musa

❮ Previous
Next ❯

Citations

Oct 3, 2020·Liver International : Official Journal of the International Association for the Study of the Liver·Adeel A Butt, Peng Yan
Feb 17, 2021·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·Giovanni MarascoGiovanni Barbara
May 7, 2021·Environmental Science and Pollution Research International·Amr El-SayedMohamed Kamel
May 26, 2021·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·Jingjing QiuYan Sun
May 20, 2021·Journal of Clinical and Translational Hepatology·Anshuman Elhence Shalimar
Aug 25, 2021·Clinics and Research in Hepatology and Gastroenterology·Min DuJue Liu
Nov 6, 2021·BMC Infectious Diseases·Andrea L MaricutoDavid A Forero-Peña

❮ Previous
Next ❯

Software Mentioned

Scopus
Comprehensive Meta ‐ analysis
Google Scholar

Related Concepts

Related Feeds

Anorexia Nervosa

Anorexia nervosa (AN) is a psychiatric condition characterized by severe weight loss and secondary problems associated with malnutrition. Here is the latest research on AN.