Gastrointestinal and oncologic outcomes of pediatric gastrointestinal lymphoma following upfront resection or biopsy of bowel masses.

Pediatric Surgery International
Mohd Yusran OthmanAmos H P Loh

Abstract

Complete upfront resection of pediatric gastrointestinal lymphomas is recommended over biopsy whenever feasible, but either approach may have adverse sequelae. We sought to compare gastrointestinal and oncological outcomes of pediatric gastrointestinal lymphomas who underwent attempted upfront resection or biopsy of the presenting bowel mass. We retrospectively reviewed charts of children with gastrointestinal lymphomas treated on LMB89 and LMB96 protocols from 2000 to 2019 who underwent upfront gastrointestinal surgery, and compared resection and biopsy groups. Of 33 children with abdominal lymphomas, 20 had upfront gastrointestinal surgery-10 each had resection or biopsy. Patients with attempted upfront resections had fewer postoperative gastrointestinal complications compared to biopsies (10% vs. 60%, p = 0.057), but longer time to chemotherapy initiation (median 11.5 vs. 4.5 days, p < 0.001). Three resection patients were surgically down-staged. Second surgeries were required in 30% and 40% of resected and biopsied patients, respectively, at median 4.6 months. Survival was similar in both groups, but better in patients on LMB96 protocol and stage II/III disease. Children with upfront attempted resection had low rates of sur...Continue Reading

References

Feb 1, 1992·Journal of Pediatric Surgery·R C Shamberger, H J Weinstein
Oct 1, 1991·Journal of Pediatric Surgery·M C StovroffR J Hutchinson
Feb 1, 1990·Archives of Surgery·I D FlemingB N Rao
May 11, 1974·British Medical Journal·I T MagrathN Harrison
Apr 1, 1995·Journal of Pediatric Surgery·D B Gahukamble, A S Khamage
Nov 1, 1993·Seminars in Surgical Oncology·J L Ternberg
Oct 16, 2002·Journal of Pediatric Surgery·Andishe AttarbaschiUNKNOWN Austrian Cooperative Study Group
Sep 19, 2003·European Journal of Pediatric Surgery : Official Journal of Austrian Association of Pediatric Surgery ... [et Al] = Zeitschrift Für Kinderchirurgie·L AbbasoğluO Görgün
Feb 7, 2006·Seminars in Pediatric Surgery·Alan P Ladd, Jay L Grosfeld
Jan 26, 2008·British Journal of Haematology·Jonathan P KerrPeter W M Johnson
Dec 4, 2010·Journal of Pediatric Hematology/oncology·Gaurav GuptaSameer Bakhshi

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