Gastrointestinal bleeds associated with rofecoxib

Pharmacotherapy
Pamela A ForalKelly K Nystrom

Abstract

Data suggest that cyclooxygenase (COX)-2 inhibitors are safer for the gastrointestinal tract than traditional nonsteroidal antiinflammatory drugs (NSAIDs). Rofecoxib, a COX-2-specific NSAID, does not inhibit the COX-1 enzyme, thereby decreasing the potential for gastrointestinal-related adverse effects. Patients who are at an increased risk for NSAID-related gastrointestinal bleeding are therefore appropriate candidates for COX-2 inhibitors. Although the agents provide benefits for many patients, gastrointestinal-related side effects may occur, and caution should be practiced when prescribing COX-2 inhibitors. We report two patients who were admitted to the hospital with diagnoses of gastrointestinal bleeds while they were taking rofecoxib.

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Citations

Nov 13, 2002·Pharmacoepidemiology and Drug Safety
Aug 9, 2003·The Journal of Pharmacy and Pharmacology·Naveen AhujaBhupinder Singh
Jan 24, 2006·Asia-Pacific Journal of Public Health·S S Chua, T Paraidathathu

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