PMID: 6976617Jan 1, 1981Paper

Gastrointestinal blood loss, gastroscopy and coagulation factors in normal volunteers during administration of acetylsalicylic acid and fluproquazone

Scandinavian Journal of Rheumatology
R GillbergG Nyberg

Abstract

The influence of one week's treatment of fluproquazone, 300 mg daily, and acetylsalicylic acid (Aspirin, Bayer), 3000 mg daily, on the gastro-intestinal tract and coagulation factors was compared in a randomized cross-over study in 12 healthy male volunteers. Gastroscopy revealed two acute erosions after fluproquazone in one subject, whereas 11 of the 12 subjects showed a total of about 80 erosions, petechiae or diffuse bleeding after aspirin. Median faecal blood loss, as assessed by means of 51Cr tagging and measurement of bulk radioactivity in a whole-body counter, were significantly (p less than 0.01) raised, from 1.8 (range 0-6.5) ml during the preceding control week to 6.0 (range 1.9-10.5) ml after treatment with aspirin. No significant difference was recorded between control and treatment weeks with fluproquazone. Mean bleeding time was significantly increased by 40% with aspirin, whereas no statistically significant change was observed with fluproquazone. The prostaglandin synthesis was not significantly influenced by fluproquazone but was almost completely suppressed by aspirin. Coagulation factor II-VII-X decreased slightly, but remained within the normal range with both drugs. This study demonstrated a markedly smalle...Continue Reading

References

Jun 19, 1975·The New England Journal of Medicine·M J StuartF A Oski
Oct 1, 1970·Acta Medica Scandinavica·K Korsan-Bengtsen
Dec 1, 1965·American Journal of Clinical Pathology·B S BullG Brecher
Jan 1, 1955·British Journal of Haematology·P L MOLLISON, N VEALL

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Citations

Oct 20, 1998·Australian and New Zealand Journal of Medicine·S ScharfN Christophidis
Jan 1, 1985·Acta Pharmacologica Et Toxicologica·O Takahashi, K Hiraga

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