Gastrointestinal cancer metastasis and lymphogenous spread: viewpoint of animal models of lymphatic obstruction

Japanese Journal of Clinical Oncology
K YamagataA Yasui

Abstract

Primary gastrointestinal cancer frequently spreads to the mesentery, omentum and other parts of the peritoneum and these deposits are generally considered to be induced by intraperitoneal seeding from the primary lesion. In this work, we examined the spread of gastrointestinal cancer from the viewpoint of lymphogenous metastasis using a rat model of mesenteric lymph vessel obstruction. With these models, we carried out mesenteric lymphangiography on the fourth and sixth postoperative days (five animals each) to examine morphological changes in the lymph vessels and lymph flow. In model animals with mesenteric lymph vessel obstruction, re-celiotomy, performed on the fourth postoperative day, revealed marked mesenteric edema and enlargement of the mesenteric lymph nodes, suggestive of lymph retention. We also carried out mesenteric lymphangiography and obtained images of extensive mesenteric lymph vessels and reflux of lymph distal to the obstruction point in all five animals. On the sixth postoperative day, we obtained lymphangiographic images of lymphatico-venous communication in the mesentery in all five animals. Thus in animals with lymph vessel obstruction, the lymph flow appeared to change to lymphatico-venous communication...Continue Reading

References

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Citations

Mar 27, 2010·Surgery Today·Kazuhide KumagaiKennichi Yamagata
Jun 14, 2006·Cancer Metastasis Reviews·Stanley P L LeongM Kitajima
Feb 21, 2004·Surgery·Hiroshi KoikeHisakazu Yamagishi
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Jun 28, 2002·Physiological Reviews·Lotta Jussila, Kari Alitalo
Jul 7, 2011·Diseases of the Colon and Rectum·Osama Al SahafHenry P Redmond

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