Gastrointestinal delivery of anti-inflammatory nanoparticles

Methods in Enzymology
Hamed LarouiDidier Merlin

Abstract

The concept of nanomedicine has risen to be the future of medicine. Advantages of using nanoobjects as vectors for drug delivery systems are numerous, such as fewer side effects due to a low drug dose, and high specificity between drug and target. Unlike systemic therapy, targeting a specific target is more efficient and less costly. In inflammatory bowel disease, including ulcerative colitis and Crohn disease, the colon represents the targeted organ. A large number of drugs are candidates for loading into nanoparticles (NPs). Small molecules, such as tripeptides and siRNA, or larger molecules, such as proteins (hormones, antibodies (Ab), etc.), can be encapsulated alone or in a complex form inside the NPs. In our studies, once NPs are synthesized and loaded with anti-inflammatory compounds, they are delivered to the colon. An efficient technique has been developed for specific NP targeting to digestive tract regions, including the colon, using a hydrogel based on electrostatic interactions between positive ions and negative polysaccharides. An in situ double cross-linking process, mediated by Ca²⁺ and SO₄²⁻, of chitosan and alginate administered to the mouse gastrointestinal (GI) tract by double gavage, is used for gel formati...Continue Reading

Citations

Sep 12, 2013·International Journal of Nanomedicine·Åsa BarrefeltMoustapha Hassan
Jul 1, 2016·Tissue Barriers·Mingzhen ZhangDidier Merlin
Aug 15, 2015·Therapeutic Delivery·Marlene LopesAntónio Ribeiro
May 9, 2014·Journal of Controlled Release : Official Journal of the Controlled Release Society·Hamed LarouiDidier Merlin
Jul 30, 2014·Laboratory Investigation; a Journal of Technical Methods and Pathology·Emilie ViennoisDidier Merlin
Jan 25, 2013·Therapeutic Delivery·Catarina Pinto ReisCatarina Rosado
Mar 21, 2020·Current Topics in Medicinal Chemistry·Prasad MinakshiPreeti Lakhani
Jun 9, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Sin-Yeang TeowKamyar Shameli
Mar 15, 2020·Microbiome·Negin KazemianSepideh Pakpour
Jul 26, 2014·Cancer Prevention Research·David G MenterErnest T Hawk

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