[Gastrointestinal diseases and osteomalacia].

Der Internist
S Thieler, J Schölmerich

Abstract

Osteomalacia is a metabolic bone disease associated with impaired mineralization of the bone due to Vitamin D and Calcium deficiency that can develop in gastrointestinal disorders. Gastrointestinal malabsorption after surgery, in disorders of the small bowl, in diseases of the hepatobiliary tree and in pancreatic insufficiency can lead to decreased enteral resorption of the fat-soluble Vitamin D and/or depletion of endogenous Vitamin D stores due to abnormal enterohepatic circulation. As a consequence of the Vitamin D deficiency in combination with the underlying condition patients develop an impaired calcium absorption resulting in hypocalcaemia, which leads to defective bone mineralization. Additionally chronic gastrointestinal inflammation and corticosteroid therapy - which is often needed in these patients - have a negative effect on bone metabolism as well. The therapy consists of oral substitution of Vitamin D and Calcium as well as sufficient sun light exposure or in severe cases the use of artificial UVB-radiation.

References

Jul 1, 1992·Journal of Internal Medicine·W A De Boer, G N Tytgat
Feb 1, 1995·Gastroenterology·V AbitbolB Amor
Oct 23, 1997·American Journal of Surgery·T T ZittelH D Becker
Sep 17, 2002·Calcified Tissue International·M L Bianchi, M T Bardella
Oct 31, 2002·American Journal of Respiratory and Critical Care Medicine·Sarah L ElkinJuliet E Compston
Mar 4, 2003·Gastroenterology·Charles N BernsteinMeryl S Leboff
May 6, 2003·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·Ristan M GreerJennifer A Batch
Jul 18, 2003·European Journal of Gastroenterology & Hepatology·Peter Vestergaard
Jul 18, 2003·European Journal of Gastroenterology & Hepatology·Charles N Bernstein, William D Leslie
Sep 2, 2003·Gastroenterology·UNKNOWN American Gastroenterological Association
Apr 27, 2004·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Maureen M J GuichelaarJ Eileen Hay
Oct 21, 2004·Best Practice & Research. Clinical Gastroenterology·Jürgen Schölmerich
Jun 21, 2005·Rheumatology International·Taoufik HarzyNajia Hajjaj-Hassouni
Jun 25, 2005·Rheumatology International·Hanène LandolsiIbtissem Ghedira
Nov 30, 2006·Nature Clinical Practice. Gastroenterology & Hepatology·Bronwyn A CrawfordGeoffrey W McCaughan
Jul 20, 2007·The New England Journal of Medicine·Michael F Holick
Sep 7, 2007·Photodermatology, Photoimmunology & Photomedicine·Prakash ChandraVin Tangpricha
Sep 22, 2007·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Jane Collier

❮ Previous
Next ❯

Citations

Jul 28, 2012·American Journal of Physiology. Gastrointestinal and Liver Physiology·Nicholas J KoszewskiJesse P Goff

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA
Bess Dawson-HughesReinhold Vieth
The New England Journal of Medicine
Michael F Holick
Nederlands tijdschrift voor geneeskunde
P L van Daele, H A Pols
© 2022 Meta ULC. All rights reserved