Gastrointestinal hormones in regulation of memory

Peptides
Anwesha MandalLokesh K Bhatt

Abstract

The connection between the gastrointestinal hormones and the brain has been established many years ago. This relation is termed the gut-brain axis (GBA). The GBA is a bidirectional communication which not only regulates gastrointestinal homeostasis but is also linked with higher emotional and cognitive functions. Hypothalamus plays a critical role in the regulation of energy metabolism, nutrient partitioning and control of feeding behaviors. Various gut hormones are released inside the gastrointestinal tract on food intake. These hormones act peripherally and influence the different responses of the tissues to the food intake, but do also have effects on the brain. The hypothalamus, in turn, integrates visceral function with limbic system structures such as hippocampus, amygdala, and cerebral cortex. The hippocampus has been known for its involvement in the cognitive function and the modulation of synaptic plasticity. This review aims to establish the role of various gut hormones in learning and memory, through the interaction of various receptors in the hippocampus. Understanding their role in memory can also aid in finding novel therapeutic strategies for the treatment of the neurological disorders associated with memory dysf...Continue Reading

Citations

Nov 27, 2018·The Journal of Endocrinology·Lenka MaletínskáJaroslav Kuneš
Jun 5, 2019·Neurochemical Research·Grace Dos Santos FeijóRenata Padilha Guedes
Jul 28, 2020·Neuroscience and Biobehavioral Reviews·Matthew J Hartsock, Robert L Spencer
Jun 22, 2021·Neuroscience and Biobehavioral Reviews·Michael D KendigMargaret J Morris

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