Gastrointestinal Involvement in Mast Cell Activation Disorders

Immunology and Allergy Clinics of North America
Fred H Hsieh

Abstract

Gastrointestinal (GI) symptoms are commonly reported in patients with mast cell disease. GI involvement in systemic mastocytosis is heterogeneous and symptoms may be caused by infiltration of abnormal mast cells in the GI tract and/or by the downstream effect of mast cell mediators on GI tissues. GI symptoms described the monoclonal mast cell activation syndrome are best characterized in the context of acute anaphylaxis. The presence of GI symptoms and a subjective response of symptoms to anti-mast cell mediator therapy are considered qualifying criteria in the diagnosis of the idiopathic mast cell activation syndrome. Antimediator therapy may help alleviate GI symptoms in mast cell disease.

Citations

Apr 25, 2020·Digestive Diseases and Sciences·Leonard B WeinstockGerhard J Molderings
Oct 24, 2018·The American Journal of Gastroenterology·Leonard B WeinstockLawrence B Afrin
Dec 2, 2020·Clinical and Translational Gastroenterology·Florencia CarboneJan Tack
Mar 13, 2021·Frontiers in Cell and Developmental Biology·Elvira Mass, Rebecca Gentek

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