Gastrointestinal manifestations of multiple endocrine neoplasia type 2

Annals of Surgery
Mark S CohenJ F Moley

Abstract

To determine the clinical features, natural history, and role of surgery for gastrointestinal manifestations of the multiple endocrine neoplasia type 2 (MEN 2) syndromes. The MEN 2 syndromes are characterized by medullary thyroid carcinoma and other endocrinopathies. In addition, some patients with MEN 2A develop Hirschsprung's disease (HD), and all patients with MEN 2B have intestinal neuromas and megacolon that can cause significant gastrointestinal problems. From 83 families with MEN 2A, eight patients with HD were identified (MEN 2A-HD). These and all patients with MEN 2B followed at the authors' institution (n = 53) were sent questionnaires to describe the onset and type of gastrointestinal symptoms and treatment they had before the diagnosis of MEN 2. Records of all patients responding were reviewed, including radiographic imaging, histology, surgical records, and genetic testing. Thirty-six of the 61 patients (59%) responded (MEN 2A = 8, MEN 2B = 28) to the questionnaires. All patients with MEN 2A-HD were operated on for HD 2 to 63 years before being diagnosed with MEN 2. All patients responding were underweight as infants and had symptoms of abdominal pain, distention, and constipation. Eighty-eight percent had hematoch...Continue Reading

References

Aug 1, 1987·Journal of Pediatric Surgery·A H KhanE Seidman
Jan 1, 1983·AJR. American Journal of Roentgenology·T C DemosP L Goldstein
Jan 1, 1982·Journal of Pediatric Gastroenterology and Nutrition·M VerdyP Brochu
Aug 1, 1980·The Journal of Clinical Endocrinology and Metabolism·M R StjernholmL J Deftos
Mar 1, 1995·Journal of Pediatric Surgery·H A HeijA Vos
Dec 1, 1994·Human Molecular Genetics·L M MulliganA Safar
May 1, 1996·Current Problems in Surgery·M A Skinner
Jul 29, 1998·Journal of Internal Medicine·G RomeoG Martucciello

❮ Previous
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Citations

Nov 9, 2006·Indian Journal of Pediatrics·Narayanan Venkatasubramani, Manu R Sood
Aug 15, 2013·Pediatric Surgery International·Florian Friedmacher, Prem Puri
Sep 20, 2007·Techniques in Coloproctology·U M MonestiroliP Danelli
Aug 29, 2003·Current Treatment Options in Oncology·Jeffrey F Moley
Jul 21, 2005·Thyroid : Official Journal of the American Thyroid Association·Maria A KouvarakiDouglas B Evans
Mar 15, 2013·Current Opinion in Otolaryngology & Head and Neck Surgery·Vincent Vander PoortenPierre Delaere
Sep 24, 2004·ANZ Journal of Surgery·Jonathan R SutcliffeJohn M Hutson
Sep 23, 2006·Annals of Surgical Oncology·José G GuillemKenneth Offit
Nov 3, 2012·Case Reports in Endocrinology·Deniz CetinMuhan Erkuş
Jun 22, 2014·Current Problems in Cancer·Amir H Lebastchi, Glenda G Callender
Oct 14, 2014·Indian Journal of Pathology & Microbiology·Eren GurkanBerrin Cetinarslan
Mar 22, 2006·Radiographics : a Review Publication of the Radiological Society of North America, Inc·Andrew F ScarsbrookRachel R Phillips
Dec 5, 2013·Expert Opinion on Drug Discovery·Michael W Sim, Mark Steven Cohen
Aug 29, 2012·Journal of Comparative Pathology·J K ParisS H Smith
Jan 18, 2012·Seminars in Pediatric Surgery·Diana L Diesen, Michael A Skinner
Jul 1, 2010·Medical Journal, Armed Forces India·A GundgurthiM K Garg
Mar 8, 2011·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Johanna IturrinoJarred M Orrock
Sep 14, 2010·Best Practice & Research. Clinical Endocrinology & Metabolism·Nelson WohllkHartmut P H Neumann
Aug 2, 2008·The Surgical Clinics of North America·Tawakalitu Oseni, Ismail Jatoi
Aug 4, 2007·Endocrinology and Metabolism Clinics of North America·Catherine Dinauer, Gary L Francis
May 21, 2003·Journal of Internal Medicine·M S Cohen, J F Moley
Jan 22, 2011·Australian Veterinary Journal·K L A HazellN Sullivan
Dec 23, 2004·Current Problems in Surgery·Roshini Dasgupta, Jacob C Langer
Jul 22, 2006·Oral Oncology·Carlos SuárezAlessandra Rinaldo
Mar 27, 2015·Thyroid : Official Journal of the American Thyroid Association·Samuel A WellsUNKNOWN American Thyroid Association Guidelines Task Force on Medullary Thyroid Carcinoma
Mar 9, 2011·Best Practice & Research. Clinical Gastroenterology·B PeetersR C Hennekam
Sep 25, 2016·Cancer Treatment Reviews·Vinicius ErnaniTaofeek K Owonikoko
Jul 13, 2016·United European Gastroenterology Journal·Denys GibbonsDeborah Eckert
Sep 30, 2006·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·José G GuillemUNKNOWN SSO
Jul 13, 2017·Endocrine-related Cancer·Frederic CastinettiSteven G Waguespack
May 11, 2005·Familial Cancer·Mariola Peczkowska, Andrzej Januszewicz
Jan 5, 2018·Nature Reviews. Gastroenterology & Hepatology·Robert O Heuckeroth
May 24, 2006·World Journal of Gastroenterology : WJG·Christina MaserSanziana Roman
Mar 26, 2008·Pediatric Hematology and Oncology·Soumen Khatua, Laura L Bilodeau
Nov 11, 2020·Clinical Endocrinology·Mariia GoncharovaMaralyn Druce
Jul 5, 2017·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Jonathan D WassermanJoshua D Schiffman

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