Gastrointestinal Manifestations of Hypereosinophilic Syndromes and Mast Cell Disorders: a Comprehensive Review

Clinical Reviews in Allergy & Immunology
Vivian C Nanagas, Anna Kovalszki

Abstract

Hypereosinophilic syndrome and mastocytosis are relatively rare proliferative diseases encountered in the general population. However, allergists frequently consider these disorders in the differential of patients presenting with gastrointestinal, pulmonary, cutaneous, and allergic symptoms. Gastrointestinal symptoms are some of the most frequent and/or debilitating aspects of both disease states and in many cases lead to poor quality of life and functional limitation for the patient. They are the third most common clinical manifestation in hypereosinophilic syndrome and have been found to be the most distressful aspect of the disorder in those with systemic mastocytosis. Both eosinophils and mast cells play integral parts in normal gut physiology, but when and how exactly their effector functionality translates into clinically significant disease remains unclear, and the available literature regarding their pathophysiology remains sparse. Eosinophils and mast cells even, in fact, may not necessarily function in isolation from each other but can participate in bidirectional crosstalk. Both are affected by similar mediators and can also influence one another in a paracrine fashion. Their interactions include both production of s...Continue Reading

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Citations

Dec 1, 2018·Oncology and Therapy·Marianna CriscuoloLivio Pagano
Aug 2, 2019·World Journal of Gastroenterology : WJG·Alexandre Loktionov
Feb 16, 2020·The Journal of Allergy and Clinical Immunology. in Practice·Gregory M ConstantineAmy D Klion
Mar 5, 2021·Gastroenterología y hepatología·Rosa María Sáiz ChumillasLorena Alba Hernández

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