Abstract
The aerobic, facultative, and anaerobic microorganisms cultivable from the stomachs, ilea, ceca, and colons of BALB/c athymic (nu/nu) mice (normal and wasting), thymus-implanted normal nude mice, and their heterozygous (nu/+) littermates were investigated. Ninety-one species representing 23 genera of bacteria and yeasts were isolated from the 27 mice. The wasting nude mice showed significantly lower numbers of lactobacilli in their stomach microbiota than did mice from the other three groups. The littermate animals appeared unique among the four groups in having corynebacteria as a major constituent of their stomach and ileal flora. The normal nude mice appeared to have a more diverse anaerobic stomach flora than their heterozygous littermates. These minor differences are discussed with respect to possible immunological, physiological, and environmental factors as their cause. Because the gastrointestinal microfloras of the mice from the four groups were not radically divergent from each other, it was concluded that loss of T-cell function does not dramatically alter the makeup of the cultivable gastrointestinal microflora in these mice.
References
Jan 1, 1977·Annual Review of Microbiology·D C Savage
Mar 1, 1976·Journal of Clinical Microbiology·D StargelV R Dowell
Mar 1, 1976·Cellular Immunology·M S Meltzer
Aug 1, 1975·Infection and Immunity·P EmmerlingJ Bockemühl
Aug 1, 1977·Applied and Environmental Microbiology·C P DavisC E Yale
Mar 1, 1976·Applied and Environmental Microbiology·L V HoldemanW E Moore
Jun 1, 1976·Applied and Environmental Microbiology·M A HarrisG R Carter
Mar 1, 1975·Applied Microbiology·J D Gillmore, F B Gordon
Dec 1, 1972·The American Journal of Clinical Nutrition·A Aranki, R Freter
Mar 1, 1974·Infection and Immunity·G W Tannock, D C Savage
Nov 22, 1974·Nature·I A Clark, A C Allison
Feb 1, 1974·Proceedings of the Society for Experimental Biology and Medicine·R L McCann, D H Sussdorf
Apr 1, 1969·Applied Microbiology·A ArankR Freter
Feb 1, 1971·The Journal of Experimental Medicine·A LeeR Dubos
Jun 1, 1969·Journal of Bacteriology·D C Savage
Jul 1, 1965·The Journal of Experimental Medicine·R DUBOSP HOET
Jun 1, 1962·The Journal of Experimental Medicine·R W SCHAEDLER, R J DUBOS
Mar 1, 1977·Applied and Environmental Microbiology·E BalishT D Wilkins
Citations
Aug 1, 1981·The Journal of Applied Bacteriology·T G Mason, G Richardson
Jan 4, 2001·Clinical and Diagnostic Laboratory Immunology·S M WiesnerC L Wells
Aug 30, 2012·Mucosal Immunology·S MashoofM F Criscitiello
Jan 1, 1982·Microbiology and Immunology·Y MorishitaK Aibara
Apr 5, 2003·Applied and Environmental Microbiology·Leanne SaitPeter H Janssen
Nov 17, 2004·Shock·Carol L WellsStanley L Erlandsen
Dec 5, 2006·Applied and Environmental Microbiology·Mai Ping TanRichard A Strugnell
Oct 12, 2011·Infection and Immunity·Katie L MasonGary B Huffnagle
Dec 10, 1999·Current Opinion in Clinical Nutrition and Metabolic Care·J C Marshall
Jun 1, 1997·Oral Microbiology and Immunology·H Marcotte, M C Lavoie
May 21, 2015·PloS One·Lei ChenW L Wendy Hsiao
Apr 11, 2019·Animals : an Open Access Journal From MDPI·Yuting LiHui Xu
Feb 1, 1980·Infection and Immunity·W E Owens, R D Berg
Mar 1, 1979·Infection and Immunity·P B Helstrom, E Balish