Gastrointestinal motor and myoelectric correlates of motion sickness

The American Journal of Physiology
I M LangR Shaker

Abstract

The objectives of this study were to characterize the digestive tract motor and myoelectric responses associated with motion sickness. Twenty-two cats (1.5-3.0 kg) were chronically implanted with force transducers and electrodes on the stomach and small intestine. Motion sickness was activated by vertical oscillation (VO) at +/-0.5 g and identified as salivation, licking, or vomiting. Vomiting was initiated chemically by UK-14304 (2.5-15 microg/kg iv) or CuSO4 (10-50 mg ig). We found that VO caused vomiting (45% of trials), a decrease in gastrointestinal (GI) motility (69% of trials), salivation or licking (59% of trials), bradygastria (39% of trials), retrograde giant contraction (RGC, 43% of trials), giant migrating contraction (GMC, 5% of trials), and defecation (18% of trials). The decrease in GI motility occurred with (62% of trials) or without (69% of trials) vomiting. Motion sickness was accompanied by bradygastria (52% of trials) and decreased GI motility (70% of trials). Similar events occurred after CuSO4 and UK-14304, but the incidences of responses after CuSO4 were less frequent, except for vomiting, RGC, and GMC. UK-14304 never caused GMCs or defecation. The magnitude and velocity of the RGC were the same during al...Continue Reading

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Citations

Apr 9, 2001·American Journal of Physiology. Gastrointestinal and Liver Physiology·H FaasP Boesiger
Jan 27, 2012·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Takeshi SuzukiBill J Yates
Mar 21, 2009·American Journal of Physiology. Gastrointestinal and Liver Physiology·G GourcerolM Million
Apr 3, 2010·Experimental Physiology·Nathalie Percie du SertPaul L R Andrews
Nov 18, 2014·World Journal of Gastroenterology : WJG·Hiroyuki AndoHiroyuki Kuwano
May 23, 2019·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·Gema VeraRaquel Abalo
Mar 10, 2012·American Journal of Physiology. Gastrointestinal and Liver Physiology·I M LangR Shaker
Aug 13, 2011·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Yoichiro SugiyamaBill J Yates
Jan 28, 2021·Frontiers in Robotics and AI·Kay StanneyLinda Foster

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