Gastrointestinal neuroimmune disruption in a mouse model of Gulf War illness

FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology
Siomara HernandezBrian D Gulbransen

Abstract

Gulf War illness (GWI) is a chronic multisymptom disorder that is prominent in Gulf War veterans. Major unexplained symptoms of GWI include functional gastrointestinal disorders and undiagnosed illnesses, including neurologic disorders. Exposure to the antinerve gas drug pyridostigmine bromide (PB) is linked to the development of GWI, but the exact mechanisms remain unclear. Here, we tested the hypothesis that PB alters gut function by disrupting the neural and immune systems of the intestine. We exposed male and female mice to physiologically comparable amounts of PB that match the dose, route, and time frame of exposure experienced by Gulf War veterans and assessed the acute and chronic impacts on gastrointestinal functions, the functional architecture of the enteric nervous system, and immune responses in the gut and brain. Exposure to PB drove acute alterations to colonic motility and structure in both male and female mice that transitioned to chronic changes in gut functions. PB drove acute alterations to enteric neural and glial activity, glial reactivity, and neuron survival with glial reactivity persisting into the chronic phase in male mice. Despite having no effect on colonic permeability, exposure to PB caused major ...Continue Reading

References

Jan 1, 1994·Baillière's Clinical Endocrinology and Metabolism·K McConalogue, J B Furness
Oct 10, 1996·Developmental Biology·M D MichaelsonJ A Kessler
Feb 3, 1998·American Journal of Respiratory Cell and Molecular Biology·A HancockA Millar
Jan 3, 2001·Blood·T A Fehniger, M A Caligiuri
Mar 26, 2002·Journal of Occupational and Environmental Medicine·Jessica WolfeHoward Hu
Oct 22, 2002·American Journal of Physiology. Gastrointestinal and Liver Physiology·Johan D SöderholmMary H Perdue
Jun 1, 2005·Brain, Behavior, and Immunity·Valentin A Pavlov, Kevin J Tracey
Jun 27, 2006·American Journal of Physiology. Gastrointestinal and Liver Physiology·Yasmin NasserKeith A Sharkey
Sep 23, 2006·American Journal of Physiology. Gastrointestinal and Liver Physiology·L WangY Taché
Feb 3, 2007·The Journal of Clinical Investigation·Kevin J Tracey
Jan 15, 2008·Journal of Neuroimmunology·Seddigheh Razani-BoroujerdiMohan L Sopori
Mar 12, 2008·Proceedings of the National Academy of Sciences of the United States of America·Beatrice Alexandra Golomb
Apr 18, 2008·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·J B Furness
May 19, 2009·Acta Pharmacologica Sinica·Jian-xin Shen, Jerrel L Yakel
May 20, 2009·The International Journal of Biochemistry & Cell Biology·Aaron James Camp, Rajiv Wijesinghe
Jul 4, 2009·Current Protocols in Neuroscience·Claudia S Caligioni
Mar 3, 2010·The Journal of Immunology : Official Journal of the American Association of Immunologists·Joshua M RosenblumRobert L Fairchild
Mar 4, 2011·The Journal of Immunology : Official Journal of the American Association of Immunologists·Ritobrata Goswami, Mark H Kaplan
Mar 18, 2011·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·M ThackerJ B Furness
Aug 2, 2011·Cytokine & Growth Factor Reviews·Mingli LiuJonathan K Stiles
Mar 7, 2012·Nature Reviews. Gastroenterology & Hepatology·John B Furness
Jul 13, 2012·The Journal of Immunology : Official Journal of the American Association of Immunologists·Takahiro HaraKoichi Ikuta
Jul 27, 2012·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·M FranceH Xu
Nov 2, 2012·The Journal of Pharmacology and Experimental Therapeutics·Kelen FreitasM Imad Damaj
Jan 28, 2014·Neuron·Joshua E Burda, Michael V Sofroniew
Jul 9, 2014·Nature Reviews. Gastroenterology & Hepatology·Stuart M Brierley, David R Linden
Oct 24, 2014·Frontiers in Immunology·Guillermo Arango Duque, Albert Descoteaux

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Citations

Oct 9, 2019·International Journal of Environmental Research and Public Health·Patricia A JanulewiczSaurabh Chatterjee
Oct 1, 2020·International Journal of Environmental Research and Public Health·Ryan S MoteNikolay M Filipov
Sep 5, 2020·Scientific Reports·Israel Ramirez-SanchezFrancisco Villarreal
Nov 1, 2020·Brain, Behavior, and Immunity·Michael J LacagninaPeter M Grace
May 16, 2021·Life Sciences·Xueqin WangChien-Liang Glenn Lin
Jun 18, 2021·Life Sciences·Saurabh ChatterjeeRatanesh Seth

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