Gastrointestinal Neurons Expressing HCN4 Regulate Retrograde Peristalsis.

Cell Reports
Kensuke FujiiFumihito Ono

Abstract

Peristalsis is indispensable for physiological function of the gut. The enteric nervous system (ENS) plays an important role in regulating peristalsis. While the neural network regulating anterograde peristalsis, which migrates from the oral end to the anal end, is characterized to some extent, retrograde peristalsis remains unresolved with regards to its neural regulation. Using forward genetics in zebrafish, we reveal that a population of neurons expressing a hyperpolarization-activated nucleotide-gated channel HCN4 specifically regulates retrograde peristalsis. When HCN4 channels are blocked by an HCN channel inhibitor or morpholinos blocking the protein expression, retrograde peristalsis is specifically attenuated. Conversely, when HCN4(+) neurons expressing channelrhodopsin are activated by illumination, retrograde peristalsis is enhanced while anterograde peristalsis remains unchanged. We propose that HCN4(+) neurons in the ENS forward activating signals toward the oral end and simultaneously stimulate local circuits regulating the circular muscle.

Citations

Aug 7, 2020·American Journal of Physiology. Gastrointestinal and Liver Physiology·Anthony C JohnsonBeverley Greenwood-Van Meerveld
Dec 20, 2020·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·Bradley S JonesPhil G Dinning
May 7, 2021·Nature Communications·Donghai LiuStanley Nattel
Aug 8, 2021·Lasers in Surgery and Medicine·Hoda Keshmiri NeghabBahram Goliaei
Aug 18, 2021·Progress in Biophysics and Molecular Biology·Patrizia BenzoniAnnalisa Bucchi

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