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Gastrointestinal Perforations with Biologics in Patients with Rheumatoid Arthritis: Implications for Clinicians

Drug Safety : an International Journal of Medical Toxicology and Drug Experience

Jun 1, 2018

Aprajita Jagpal, Jeffrey R Curtis

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Abstract

Gastrointestinal (GI) perforations are rare events in rheumatoid arthritis (RA) patients, but cause significant morbidity and mortality. Several studies indicate that RA patients may be at higher risk of GI perforation. Traditional RA treatments such as glucocorticoids and non-steroidal...read more

Mentioned in this Paper

Biological Products
Morbidity Aspects
Steroidal anti-inflammatory drugs
Therapeutic agent (substance)
Glucocorticoids
Relative Risk
IL6 gene
Therapeutic Agent
Interleukin-6 Binding Activity
Glucocorticoids, Systemic
26
2
8
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Gastrointestinal Perforations with Biologics in Patients with Rheumatoid Arthritis: Implications for Clinicians

Drug Safety : an International Journal of Medical Toxicology and Drug Experience

Jun 1, 2018

Aprajita Jagpal, Jeffrey R Curtis

PMID: 29392593

DOI: 10.1007/s40264-018-0639-1

Abstract

Gastrointestinal (GI) perforations are rare events in rheumatoid arthritis (RA) patients, but cause significant morbidity and mortality. Several studies indicate that RA patients may be at higher risk of GI perforation. Traditional RA treatments such as glucocorticoids and non-steroidal...read more

Mentioned in this Paper

Biological Products
Morbidity Aspects
Steroidal anti-inflammatory drugs
Therapeutic agent (substance)
Glucocorticoids
26
2
8

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Paper Details
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  • References49
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