PMID: 6112753Mar 1, 1981Paper

Gastrointestinal secretory, motor, circulatory, and metabolic effects of prosomatostatin

Proceedings of the National Academy of Sciences of the United States of America
S J KonturekA V Schally

Abstract

This study compares the gastrointestinal effects of somatostatin (SS) and its putative prohormone, prosomatostatin (Pro-SS), a 28-amino acid peptide isolated from the hypothalamus and the gut, in conscious dogs with chronic gastric and pancreatic fistulae. Pro-Ss suppressed the release of serum gastrin, insulin, and pancreatic polypeptide that occurs in response to feeding a meat meal in a manner similar to that seen with SS. However, in contrast to SS, which strongly reduced intestinal blood flow and oxygen consumption and stimulated intestinal motility, Pro-SS, at the doses tested, had no influence on mesenteric circulation, oxygen uptake, and intestinal motility. We conclude that Pro-SS mimics most of the gastrointestinal secretory actions of SS, but does not exhibit the intestinal circulatory, metabolic, and motor effects of SS.

References

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Citations

Sep 1, 1984·Neuroscience and Behavioral Physiology·G M BarashkovaM V Andrianova
Nov 1, 1987·The Journal of Surgical Research·R P CambriaI M Modlin
Dec 15, 1983·The New England Journal of Medicine·S Reichlin
Apr 1, 1986·Gut·M R Lucey
Jan 1, 1987·Scandinavian Journal of Gastroenterology. Supplement·T Hedner, J Cassuto
Oct 1, 1990·The American Journal of the Medical Sciences·N J Brown
Nov 1, 1986·Clinical Immunology and Immunopathology·K VehmeyerG A Nagel
Jan 1, 1991·Journal of Hepatology·T BarrecaE Rolandi
Dec 1, 1986·Scandinavian Journal of Gastroenterology·S J Konturek, M E Kitler
Jan 1, 1987·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·R H GoodmanG Mandel
Feb 1, 1991·Scandinavian Journal of Gastroenterology·P LayerC Beglinger
Sep 1, 1990·International Journal of Peptide and Protein Research·A V SchallyR Z Cai
Aug 1, 1987·International Journal of Pancreatology : Official Journal of the International Association of Pancreatology·S J KonturekJ Bilski

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