Gastrointestinal stromal tumor, uncommitted type, with monosomies 14 and 22 as the only chromosomal abnormalities

Cancer Genetics and Cytogenetics
V MarciM Risio

Abstract

Karyotypic analysis of a gastric stromal tumor with the histologic and immunohistochemical features of a malignant, uncommitted lesion revealed clonal monosomies of chromosomes 14 and 22. Such changes, together with loss of chromosomes 15 and 18, as well as structural rearrangements involved chromosome 1, have been previously reported in gastrointestinal stromal tumors with smooth muscle differentiation. We suggest that monosomies of chromosomes 14 and 22 are early events in the malignant transformation of the mesenchymal cell-originating gastrointestinal stromal tumors.

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Citations

Aug 16, 2000·Cancer Genetics and Cytogenetics·J A BreinerJ A Bridge
Jul 17, 2001·Cancer Genetics and Cytogenetics·M Debiec-RychterM Miettinen
Jun 20, 2002·Cancer Genetics and Cytogenetics·Avery A Sandberg, Julia A Bridge
Jun 4, 2008·Sarcoma·N de S Somerhausen, C D Fletcher
Sep 19, 2003·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Giancarlo PruneriGiuseppe Viale
Dec 30, 2006·Seminars in Diagnostic Pathology·José Antonio López-GuerreroAntonio Llombart-Bosch
Aug 9, 2001·International Journal of Surgical Pathology·Brian P. RubinChristopher D. M. Fletcher
Aug 19, 2003·European Journal of Gastroenterology & Hepatology·Thomas MussackKlaus Hallfeldt
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May 30, 2001·Cancer Control : Journal of the Moffitt Cancer Center·L StricklandC A Muro-Cacho
Aug 23, 2002·Pathology·Adrienne L MoreyRobyn L Ward

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