Gastrointestinal stromal tumors: a comprehensive review

Journal of Gastrointestinal Oncology
Trisha M ParabGudata S Hinika

Abstract

Gastrointestinal stromal tumors (GISTs) are rare neoplasms of the gastrointestinal tract associated with high rates of malignant transformation. Most GISTs present asymptomatically. They are best identified by computed tomography (CT) scan and most stain positive for CD117 (C-Kit), CD34, and/or DOG-1. There have been many risk stratification classifications systems which are calculated based on tumor size, mitotic rate, location, and perforation. The approaches to treating GISTs are to resect primary low-risk tumors, resect high-risk primary or metastatic tumors with imatinib 400 mg daily for 12 months, or if the tumor is unresectable, neoadjuvant imatinib 400 mg daily followed by surgical resection is recommended. Sunitinib is required for KIT exon 9, 13, and 14 mutations, while ponatinib is used for exon 17 mutations and regorafenib for highly refractory tumors. High-risk tumors should be monitored for recurrence with serial abdominal CT scans. Radiofrequency ablation has shown to be effective when surgery is not suitable. Newer therapies of ipilimumab, nivolumab, and endoscopic ultrasound alcohol ablation have shown promising results. This report addresses the epidemiology, clinical presentation, diagnostic imaging, histolog...Continue Reading

Citations

Oct 3, 2019·Current Opinion in Gastroenterology·George Mantese
Oct 30, 2019·Journal of Gastrointestinal Cancer·Gabriel O OgunOjevwe H Egbo
Jun 18, 2020·Cancer Management and Research·Fangxing Peng, Yao Liu
Jul 31, 2020·Oxford Medical Case Reports·Syamim JohanAndee Dzulkarnaen Zakaria
Sep 15, 2020·World Journal of Gastroenterology : WJG·Roberto CannellaTommaso Vincenzo Bartolotta
Aug 11, 2020·World Journal of Gastroenterology : WJG·Gianluca BusinelloMatteo Fassan
Aug 8, 2020·Asia-Pacific Journal of Clinical Oncology·Domenico AlbanoFrancesco Bertagna
Jul 28, 2020·Obesity Surgery·J A FernándezJ J Ruiz-Manzanera
Oct 11, 2020·Journal of Magnetic Resonance Imaging : JMRI·Linsha YangLanxiang Liu
Nov 11, 2020·Scientific Reports·Licínia SantosSusann Teneberg
Feb 14, 2021·Journal of Clinical Medicine·Seong Ji ChoiHang Lak Lee
Nov 11, 2020·Korean Journal of Radiology : Official Journal of the Korean Radiological Society·Jiejin YangXiaoying Wang
Jan 15, 2021·The American Journal of Medicine·Siddharth AgarwalStephanie L Hansel
Jan 10, 2021·International Journal of Molecular Sciences·Christos VallilasMichalis V Karamouzis
Jan 9, 2021·Curēus·Sherif Monib, Hany F Habashy
Dec 10, 2020·Annals of Medicine and Surgery·Gregorio Arellano-GutiérrezEdwin Leopoldo Maldonado-García
Mar 13, 2021·Surgical Oncology Clinics of North America·Hanna GarnierSanjeev A Vasudevan
Jan 6, 2021·International Journal of Surgery Case Reports·William G AguayoA Katherine Romero
May 3, 2021·American Journal of Surgery·Kyle J HitscherichJoseph J Bennett
May 26, 2021·Cytopathology : Official Journal of the British Society for Clinical Cytology·Yonca KanberManon Auger
May 28, 2021·World Journal of Gastrointestinal Oncology·Mustafa Erdem ArslanHwajeong Lee
Aug 3, 2021·Curēus·Amit R HudgiJohn Erikson L Yap
Aug 10, 2021·Journal of Gastroenterology and Hepatology·Wei SuPinghong Zhou
Aug 28, 2021·Diagnostics·Irene Alexandra SpiridonIrina Draga Căruntu
Aug 27, 2021·Experimental and Therapeutic Medicine·Mihai CeausuZenaida Ceausu
Oct 28, 2021·ANZ Journal of Surgery·Zarif YahyaAhmad Aly

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Revista Española De Enfermedades Digestivas : Organo Oficial De La Sociedad Española De Patología Digestiva
F Macías-GarcíaJ E Domínguez-Muñoz
Cancer Research and Treatment : Official Journal of Korean Cancer Association
Ji Seon OhYoon-Koo Kang
Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract
Gerd R SilberhumerJohannes Zacherl
© 2022 Meta ULC. All rights reserved