Gastrointestinal Stromal Tumors: A Guide to the Diagnosis

Surgical Pathology Clinics
Joseph A HoldenLester J Layfield

Abstract

Gastrointestinal stromal tumors (GISTs) have emerged from being a poorly understood and therapeutically refractory sarcoma to a tumor whose biology has not only provided insight into a mechanism of oncogenesis but has also led to a rational basis for therapy. Most GISTs are characterized by KIT protein (CD117) expression and constitutive activating mutations in either the c-kit or platelet-derived growth factor receptor α genes. This information can now be obtained from routine formalin-fixed and paraffin-embedded tissue. Because the correct diagnosis is the key to successful treatment of this tumor, it is incumbent on the pathologist to be familiar with the various gross and histologic patterns shown by these tumors. GISTs range from small incidental stromal nodules to large cystic and solid tumor masses. GISTs show a variety of microscopic patterns and therefore several other tumors enter the differential diagnosis. Fortunately, with an understanding of GIST histology, and with the proper use of immunohistochemistry and molecular analysis, a correct diagnosis can usually be made. In addition to the correct diagnosis, several key attributes of the tumor need to be determined because they provide the basis for proper clinical m...Continue Reading

References

Sep 1, 1983·The American Journal of Surgical Pathology·M T Mazur, H B Clark
May 20, 1998·International Journal of Cancer. Journal International Du Cancer·S L TaylorR Barraclough
Apr 5, 2001·The New England Journal of Medicine·B J DrukerC L Sawyers
Jul 27, 2001·Pathology International·S SakuraiM Fukayama
Feb 28, 2002·American Journal of Clinical Pathology·Jason L Hornick, Christopher D M Fletcher
May 10, 2002·The American Journal of Pathology·Christopher L CorlessMichael C Heinrich
Jul 3, 2002·Human Pathology·Christopher D M FletcherSharon W Weiss
Aug 16, 2002·The New England Journal of Medicine·George D DemetriHeikki Joensuu
Aug 23, 2002·Pathology·Adrienne L MoreyRobyn L Ward
Sep 26, 2002·Archives of Pathology & Laboratory Medicine·Vinod B ShidhamRichard Komorowski
Jan 11, 2003·Science·Michael C HeinrichJonathan A Fletcher
Jan 17, 2003·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Allan T van OosteromUNKNOWN European Organisation for Research and Treatment of Cancer Soft Tissue and Bone Sarcoma Group
Apr 8, 2003·Current Medicinal Chemistry. Anti-cancer Agents·J A Holden
Apr 15, 2003·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Joel K Greenson
Oct 2, 2003·Gastric Cancer : Official Journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association·Yoshihide NagasakoHidetoshi Sato
Dec 4, 2003·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Michael C HeinrichJonathan A Fletcher
Dec 26, 2003·The American Journal of Pathology·Kathleen KemmerMichael C Heinrich
Feb 24, 2004·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Mark E RobsonKenneth Offit
Apr 17, 2004·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·K NasuI Miyakawa
Apr 17, 2004·The American Journal of Surgical Pathology·Hidetaka YamamotoMasazumi Tsuneyoshi
May 5, 2004·The Journal of Biological Chemistry·Clifford D MolKeith P Wilson
Jun 30, 2004·The American Journal of Surgical Pathology·Fabiola MedeirosChristopher D M Fletcher
Dec 8, 2004·Cellular and Molecular Life Sciences : CMLS·Y Kitamura, S Hirotab
Apr 20, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Frederick P LiGeorge D Demetri
Jun 2, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Christopher L CorlessMichael C Heinrich
Jun 3, 2005·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Cristina R AntonescuRonald P DeMatteo
Jun 17, 2005·The American Journal of Surgical Pathology·Julie A IrvingRobert H Young
Sep 1, 2005·Biochemical and Biophysical Research Communications·Robert Roskoski
Nov 1, 2005·Laboratory Investigation; a Journal of Technical Methods and Pathology·Jerzy LasotaMarkku Miettinen
Jan 28, 2006·Gynecologic Oncology·Rosemary FosterMichael V Seiden
Feb 21, 2006·Gynecologic Oncology·Alejandro SalvatierraCarmen Balaña

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Citations

Oct 13, 2012·Applied Immunohistochemistry & Molecular Morphology : AIMM·Michelle L WallanderRobert L Schmidt
Dec 20, 2011·Proceedings. Biological Sciences·J L QuinnW Cresswell
Jul 25, 2019·American Journal of Clinical Pathology·Bronwyn H BryantAlexandra N Kalof
May 31, 2018·Iranian Journal of Biotechnology·Rashid SaifMuhammad Wasim
Aug 6, 2014·Clinical Anatomy : Official Journal of the American Association of Clinical Anatomists & the British Association of Clinical Anatomists·Jessica J WhiteElmus G Beale
May 10, 2017·Future Oncology·Carla BartoschJosé Manuel Lopes

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