Gastrointestinal stromal tumors: A multidisciplinary challenge

World Journal of Gastroenterology : WJG
Juan Manuel Sanchez-HidalgoJavier Briceño-Delgado

Abstract

Gastrointestinal stromal tumors (GISTs) are the most common mesenchymal tumors located in the alimentary tract. Its usual manifestation is gastrointestinal bleeding. However, small asymptomatic lesions are frequently detected as incidental finding. Characteristically, most GISTs (> 95%) are positive for the KIT protein (CD117) by IHC staining and approximately 80%-90% of GISTs carry a mutation in the c-KIT or PDGFRA genes. Mutational analysis should be performed when planning adjuvant and neoadjuvant therapy, due to its possible resistance to conventional treatment. The arise of tyrosine kinase inhibitor has supposed a revolution in GISTs treatment being useful as adjuvant, neoadjuvant or recurrence disease treatment. That is why a multidisciplinary approach to this disease is required. The correct characterization of the tumor at diagnosis (the diagnosis of recurrences and the evaluation of the response to treatment with tyrosine kinase inhibitors) is fundamental for facing these tumors and requires specialized Endoscopist, Radiologists and Nuclear Medicine Physician. Surgery is the only potentially curative treatment for suspected resectable GIST. In the case of high risk GISTs, surgery plus adjuvant Imatinib-Mesylate for 3 y...Continue Reading

References

Apr 13, 1999·The American Journal of Surgical Pathology·K SircarR H Riddell
Sep 27, 2001·Annals of Surgery·R P DeMatteoM F Brennan
Feb 22, 2002·American Journal of Medical Genetics·J Aidan Carney, Constantine A Stratakis
Jul 3, 2002·Human Pathology·Christopher D M FletcherSharon W Weiss
Aug 16, 2002·The New England Journal of Medicine·George D DemetriHeikki Joensuu
Mar 18, 2003·Radiographics : a Review Publication of the Radiological Society of North America, Inc·Angela D LevyMarkku Miettinen
Oct 30, 2003·Scandinavian Journal of Surgery : SJS : Official Organ for the Finnish Surgical Society and the Scandinavian Surgical Society·I Besana-CianiR Dionigi
Oct 19, 2004·European Journal of Gastroenterology & Hepatology·Alfonso S SerraltaJosé P Mir
Jan 19, 2005·The American Journal of Gastroenterology·Thomas TranHashem B El-Serag
May 17, 2005·Journal of Surgical Oncology·Michael C Heinrich, Christopher L Corless
Jun 25, 2005·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·S BonvalotD Elias
Sep 20, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Daniel PinkPeter Reichardt
Dec 20, 2005·Histopathology·B P Rubin
Jan 24, 2006·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·T L HustedJ F Buell
Feb 28, 2006·Surgical Endoscopy·S Q NguyenS H Dikman
May 20, 2006·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Chandrajit P RautMonica M Bertagnolli
Jun 15, 2006·Annals of Surgery·Yuri W NovitskyB Todd Heniford
Jul 22, 2006·Annals of Surgery·Jason S Gold, Ronald P Dematteo
Sep 8, 2006·Annals of Surgical Oncology·S BonvalotA Le Cesne
Oct 31, 2006·Annals of Surgical Oncology·Robert H I AndtbackaBarry W Feig
Nov 9, 2006·Archives of Pathology & Laboratory Medicine·Markku Miettinen, Jerzy Lasota
Dec 30, 2006·Seminars in Diagnostic Pathology·Markku Miettinen, Jerzy Lasota
Jun 17, 2008·The Oncologist·Annick D Van den Abbeele
Aug 1, 2008·Journal of Surgical Oncology·Marco ScarpaImerio Angriman
Sep 10, 2008·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Daniela GasparottoRoberta Maestro
Dec 23, 2008·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·E A EisenhauerJ Verweij
Feb 3, 2009·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·Ying-Jiang YeShan Wang
Feb 21, 2009·Journal of the American College of Surgeons·Parissa TabrizianCelia M Divino
Mar 24, 2009·Lancet·Ronald P DematteoUNKNOWN American College of Surgeons Oncology Group (ACOSOG) Intergroup Adjuvant GIST Study Team
Aug 12, 2009·Seminars in Oncology·Peter ReichardtPatrick Schöffski

❮ Previous
Next ❯

Citations

Oct 4, 2019·Oncology Letters·Linwei ZhangJing Wang
Aug 24, 2018·Biomedicines·Shaker A MousaPaul J Davis
May 24, 2020·Journal of Gastrointestinal Cancer·Mustafa ŞentürkÖmer Kişi
Feb 29, 2020·World Journal of Clinical Cases· Rare Tumors Gi GroupRafid A Abood
Apr 5, 2020·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Carlos BenítezJorge A Martínez
Feb 9, 2020·BMJ Case Reports·Arwa Ahmed Ashoor, Ghaith Barefah
Oct 2, 2020·Applied Immunohistochemistry & Molecular Morphology : AIMM·Si WangYang Liu
Jun 26, 2020·Physiological Reviews·Paul J DavisHung-Yun Lin
Jan 28, 2021·AJR. American Journal of Roentgenology·Jonathan M GanNikhil H Ramaiya
May 22, 2021·SAGE Open Medical Case Reports·Takahisa YamaguchiSachio Fushida
Aug 27, 2021·Experimental and Therapeutic Medicine·Mihai CeausuZenaida Ceausu

❮ Previous
Next ❯

Methods Mentioned

BETA
biopsy
biopsies
gastric
amputation
surgical resection
imaging techniques

Clinical Trials Mentioned

NCT02413736
NCT02260505

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

The Surgical Clinics of North America
Emily Z Keung, Chandrajit P Raut
Cancer Research and Treatment : Official Journal of Korean Cancer Association
Ji Seon OhYoon-Koo Kang
Current Treatment Options in Oncology
Emily Z KeungChandrajit P Raut
© 2022 Meta ULC. All rights reserved