Gastrointestinal stromal tumors: clinical profile, pathogenesis, treatment strategies and prognosis

Journal of Gastroenterology and Hepatology
Arash NowainSumita Verma


Abstract Gastrointestinal stromal tumors (GIST), although the most common mesenchymal neoplasms of the gastrointestinal (GI) tract, account for <1% of all GI malignancies. Up to 94% of these tumors express the CD117 antigen. Most patients present in the fifth to seventh decade, the commonest symptom being that of an abdominal mass. Surgery is the main modality of therapy, but even after adequate resection the vast majority of GIST reoccur, and in approximately 50% the liver is the main site of the metastasis. Long-term, maybe even lifelong follow up of these patients after initial resection cannot be over-emphasized. Initial tumor size and mitotic rate are the most useful parameters to predict malignant potential. In view of high postoperative recurrence, adjuvant forms of therapy are being explored, and the tyrosine kinase inhibitor imatinib holds the most promise.


Sep 1, 1978·Cancer·O E AkwariO H Beahrs
Jun 30, 1977·The New England Journal of Medicine·J A CarneyH Gordon
Aug 1, 1976·Cancer·H D Appleman, E B Helwig
Jun 1, 1992·American Journal of Surgery·C P KarakousisU Rao
Feb 1, 1988·The British Journal of Surgery·L J HeC C Chen
Dec 1, 1987·Annals of Surgery·P C McGrathG A Parker
Sep 1, 1983·The American Journal of Surgical Pathology·M T Mazur, H B Clark
May 1, 1994·Annals of Surgical Oncology·W CarsonM L Palmer
Jan 1, 1995·Annals of Surgical Oncology·K C ConlonM F Brennan
Jun 1, 1997·Gastrointestinal Endoscopy·A ChakM V Sivak
Jul 1, 1997·Biology of Reproduction·H FengA Sandra
Oct 24, 1997·The Journal of Allergy and Clinical Immunology·H VliagoftisD D Metcalfe
Jan 13, 1998·Biochimica Et Biophysica Acta·K S Kolibaba, B J Druker
Apr 16, 1998·American Journal of Clinical Pathology·L G DoddM Gottfried
Dec 3, 1998·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·H ChenM A Choti
Jan 15, 1999·The American Journal of Surgical Pathology·T S EmoryT J O'Leary
Apr 24, 1999·The British Journal of Surgery·D LevM Gutman
Jan 5, 2000·The Journal of Clinical Investigation·B J Druker, N B Lydon
Mar 7, 2000·The American Journal of Pathology·M L LuxJ A Fletcher
Jul 26, 2000·Hematology/oncology Clinics of North America·M L Taylor, D D Metcalfe
Oct 18, 2000·Annals of Surgical Oncology·I PidhoreckyJ F Gibbs
Feb 24, 2001·Journal of Clinical Pathology·J F Graadt van RoggenP C Hogendoorn
Apr 5, 2001·The New England Journal of Medicine·B J DrukerC L Sawyers
Aug 9, 2001·International Journal of Surgical Pathology·Brian P. RubinChristopher D. M. Fletcher
Nov 14, 2001·Lancet·A T van OosteromUNKNOWN European Organisation for Research and Treatment of Cancer Soft Tissue and Bone Sarcoma Group

❮ Previous
Next ❯


Dec 5, 2006·Advances in Therapy·Bulent KilicogluHuseyin Ustun
Apr 28, 2006·International Journal of Colorectal Disease·Marcovalerio MelisAlessandro Fichera
Jul 31, 2007·Surgical Endoscopy·Sanjoy BasuNick Davies
Jan 5, 2013·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·C C XiaoG X Cai
Jun 2, 2010·Journal of Gastrointestinal Cancer·Guy D Eslick, Jamshid S Kalantar
Nov 24, 2012·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Lindsey OudijkWinand N M Dinjens
Jun 15, 2006·Annals of Surgery·Yuri W NovitskyB Todd Heniford
Feb 23, 2007·Clinical Nuclear Medicine·Anna A Hansen, Ronald J Rosenberg
Aug 24, 2010·Surgical Laparoscopy, Endoscopy & Percutaneous Techniques·Yasumitsu HiranoOsamu Hosokawa
Oct 31, 2006·Journal of Clinical Pathology·A S-Y Leong, T Y-M Leong
Sep 26, 2013·AJR. American Journal of Roentgenology·Sree Harsha TirumaniNikhil H Ramaiya
Apr 29, 2009·World Journal of Gastroenterology : WJG·Yan-Jun LiuXiao-Ting Wu
Apr 30, 2011·World Journal of Gastroenterology : WJG·Simone ArolfoMario Nano
May 7, 2011·Saudi Journal of Gastroenterology : Official Journal of the Saudi Gastroenterology Association·Ehab El-HanafyEhab Atif
Mar 29, 2014·Indian Journal of Surgical Oncology·Abid IqbalT B Culas
Nov 28, 2007·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Fausto CatenaAntonio Pinna
Feb 17, 2010·Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·Manuel García de Polavieja CarrascoMarta Mayorga Fernández
May 28, 2011·World Journal of Surgical Oncology·Theodosios TheodosopoulosGeorgios Polymeneas
Nov 2, 2012·World Journal of Surgical Oncology·Ki-Han KimHyuk-Chan Kwon
Feb 3, 2009·Journal of the Formosan Medical Association = Taiwan Yi Zhi·Yi ChenChing-Cherng Tzeng
Jan 14, 2016·Journal of Gastrointestinal Cancer·Kutay SağlamAdnan Çalık
Mar 12, 2008·HPB : the Official Journal of the International Hepato Pancreato Biliary Association·D GomezK R Prasad
Mar 12, 2008·HPB : the Official Journal of the International Hepato Pancreato Biliary Association·Gregor A StavrouKarl J Oldhafer
May 25, 2010·Cirugía española·Juan Angel FernándezPascual Parrilla
Jun 2, 2009·Gastrointestinal Endoscopy·Paul S SepeWilliam R Brugge
Jan 13, 2009·Gastrointestinal Endoscopy·Siyu SunQingjie Lü
May 10, 2008·American Journal of Surgery·Mikihito NakamoriHiroki Yamaue
Feb 1, 2008·Surgical Oncology·Puneet GuptaHari S Shukla
Dec 18, 2007·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·T G HopkinsD Stark
Nov 10, 2011·Journal of Surgical Oncology·Travis E Grotz, John H Donohue
Oct 1, 2015·Current Problems in Diagnostic Radiology·Bethany MillironCourtney Coursey Moreno
Apr 13, 2010·International Journal of Surgery·Sheila S FerreiraBernardo Garicochea
Apr 19, 2011·Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics·Hussein Hassan Hamed IbrahimPetr Schuütz
Oct 28, 2017·Current Treatment Options in Gastroenterology·Kambiz KadkhodayanRobert H Hawes
Dec 5, 2012·The Journal of International Medical Research·X-J WuD-S Wan
Apr 24, 2013·Journal of Gastric Cancer·Seong-Ho Kong, Han-Kwang Yang
May 24, 2012·The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi·Hyo Sun SeokHyun Sun Won
Oct 5, 2007·Journal of Gastroenterology and Hepatology·Maria Grazia FontanaVincenzo Villanacci
Feb 14, 2007·Journal of Gastroenterology and Hepatology·Akihiko TakedaHirotoshi Sato

❮ Previous
Next ❯

Related Concepts

Trending Feeds


Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.


Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.


Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

The American Journal of Surgical Pathology
M T Mazur, H B Clark
Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology
Christopher L CorlessMichael C Heinrich
© 2022 Meta ULC. All rights reserved