PMID: 9440666Jan 24, 1998Paper

Gastrointestinal symptoms following consumption of olestra or regular triglyceride potato chips: a controlled comparison

JAMA : the Journal of the American Medical Association
L J CheskinT Filloon

Abstract

Olestra, a nonabsorbable, energy-free fat substitute used in snack foods, has been anecdotally reported to cause gastrointestinal (GI) adverse events, although such effects were not expected based on results from randomized trials, in which it was consumed in typical snack patterns. To determine whether ad libitum consumption of potato chips made with the fat substitute olestra results in a different level of GI symptoms than regular chips made with triglyceride (TG). Randomized, double-blind, parallel, placebo-controlled trial. A suburban Chicago, III, multiplex cinema. A total of 1123 volunteers aged 13 to 88 years. Subjects were given a beverage and an unlabeled, white 369-g (13-oz) bag of potato chips made with olestra or TG during a free movie screening. Total and specific GI symptoms reported during a telephone interview conducted from 40 hours to 10 days after ingestion; level of potato chip consumption; and satiety level. Of 563 evaluable subjects in the olestra chip group, 89 (15.8%) reported 1 or more GI symptoms, while 93 (17.6%) of the 529 evaluable subjects in the regular TG chip group did so (difference in symptom frequency between olestra and TG, -1.8; 95% confidence interval, -6.2 to 2.7; P=.47). For specific GI...Continue Reading

Citations

Oct 21, 1999·Lipids·R J JandacekP Y Lin
Oct 1, 2010·Journal of Food Science and Technology·Ashish S PatelSuneeta V Pinto
Jul 18, 2002·Obesity Reviews : an Official Journal of the International Association for the Study of Obesity·A L EldridgeJ C Peters
Jun 27, 2003·Journal of Pediatric Gastroenterology and Nutrition·Tamar F Barlam, Eric McCloud
Jan 9, 1999·Alimentary Pharmacology & Therapeutics·A B ThomsonN L Zorich
May 15, 2001·Regulatory Toxicology and Pharmacology : RTP·G S AllgoodN L Zorich
Apr 2, 1999·Obesity Research·E N ZayatL J Cheskin
May 16, 2000·The American Journal of Gastroenterology·J McRorieC Rudolph
Oct 26, 2002·The American Journal of Clinical Nutrition·George A BrayJohn C Peters
May 23, 2002·The Annals of Pharmacotherapy·Amy M HeckJack A Yanovski
Aug 3, 2001·Primary Care·S Bashir, T O Lipman

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