Gastrointestinal system involvement in systemic lupus erythematosus

Lupus
Z LiX Zeng

Abstract

Systemic lupus erythematosus (SLE) is a multisystem disorder which can affect the gastrointestinal (GI) system. Although GI symptoms can manifest in 50% of patients with SLE, these have barely been reviewed due to difficulty in identifying different causes. This study aims to clarify clinical characteristics, diagnosis and treatment of the four major SLE-related GI system complications: protein-losing enteropathy (PLE), intestinal pseudo-obstruction (IPO), hepatic involvement and pancreatitis. It is a systematic review using MEDLINE and EMBASE databases and the major search terms were SLE, PLE, IPO, hepatitis and pancreatitis. A total of 125 articles were chosen for our study. SLE-related PLE was characterized by edema and hypoalbuminemia, with Technetium 99m labeled human albumin scintigraphy (99mTc HAS) and alpha-1-antitrypsin fecal clearance test commonly used as diagnostic test. The most common site of protein leakage was the small intestine and the least common site was the stomach. More than half of SLE-related IPO patients had ureterohydronephrosis, and sometimes they manifested as interstitial cystitis and hepatobiliary dilatation. Lupus hepatitis and SLE accompanied by autoimmune hepatitis (SLE-AIH overlap) shared simi...Continue Reading

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Citations

Dec 22, 2019·BMJ Case Reports·Kevin JohnTarun George
May 2, 2019·Clinical Journal of Gastroenterology·Giovanna Del Vecchio BlancoOmero Alessandro Paoluzi
Oct 10, 2020·Rheumatology International·Mohammad Mustafa, Yasser Mohammed Bawazir
Nov 12, 2020·Revista da Associação Médica Brasileira·Semra Demirli AtıcıCem Tuğmen
Mar 27, 2021·Clinical Case Reports·Myriam AyariTaieb Jomni
Sep 28, 2021·Orphanet Journal of Rare Diseases·Long ChenFang He

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Methods Mentioned

BETA
biopsies
biopsy
X-ray

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