Gastrointestinal tolerance of erythritol-containing beverage in young children: a double-blind, randomised controlled trial

European Journal of Clinical Nutrition
E Jacqz-AigrainP de Cock

Abstract

To determine gastrointestinal (GI) responses and maximum tolerated dose of erythritol in young children given as a single oral dose in a 250-ml non-carbonated fruit-flavoured beverage in between meals. This is a multicentre double-blind study with sequential design for multiple dose groups and randomised crossover for comparators of placebo vs dose. A total of 185 healthy young children aged 4-6 years were recruited at three clinical investigation centres after informed consent of both parents; 184 children completed the study. Children were included in one of the four dose groups (5, 15, 20 or 25 g erythritol) and exposed randomly to only one single dose vs an isosweet sucrose placebo. After consumption in the clinic and an observation period, GI symptoms and stooling patterns were recorded during the next 48 h. Statistically significantly more episodes of diarrhoea and/or severe GI symptoms were observed in the 20 and 25  g groups compared with placebo, but not in the 5 and 15  g groups. Stool consistency, as measured by Bristol stool scale, was lower in the 15-, 20- and 25 g groups for the first 24 -h period, but not at later time points. Incidences of nausea, vomiting, borborygmi, excess flatus and abdominal pain were not s...Continue Reading

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Citations

Sep 17, 2016·International Journal of Dentistry·Peter de CockAlex Eapen
Jan 23, 2018·Advances in Dental Research·P de Cock
Oct 16, 2019·Journal of Medicinal Food·Hannah ParuzynskiJoanne Slavin
Jun 18, 2019·Critical Reviews in Food Science and Nutrition·Bettina K WölnerhanssenMd Shahidul Islam

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