Gastrokinetic activity of Morinda citrifolia aqueous fruit extract and its possible mechanism of action in human and rat models

Journal of Ethnopharmacology
Sawpheeyah NimaSirima Mahattanadul

Abstract

This study was to investigate the gastrokinetic activity of Morinda citrifolia aqueous fruit extract (AFE) in human subjects by examining the GI absorption of ranitidine, a putative indicator of GI motility and to elucidate its possible gastrokinetic mechanism of action in rats. The single-dose, randomized, open-label and 2-period crossover study was performed on 20 Thai healthy volunteers with a washout period of 14 day between the doses. AFE or drinking water was administered orally 30 min prior to a single oral administration of ranitidine (300 mg). Blood samples were collected over a 12 h period after drug administration and the pharmacokinetic parameters of ranitidine were calculated. The gastrokinetic mechanism of action of AFE was elucidated by measurement of its contractile response on the isolated rat gastric fundus strip. The area under the plasma ranitidine concentration-time curve and the maximal plasma ranitidine concentration were significantly increased after pretreatment with AFE (p=0.001). The plasma ranitidine concentrations were significantly greater at 30-120 min after its administration. AFE produced a definite contractile response of a rat gastric fundus strip with a dose dependency. Scopoletin at the same...Continue Reading

References

Jun 1, 1979·Planta medica·O Levand, H O Larson
May 23, 1998·Annual Review of Pharmacology and Toxicology·K E Thummel, G R Wilkinson
Sep 16, 2003·Journal of Pharmaceutical and Biomedical Analysis·Dragica Zendelovska, Trajce Stafilov
Sep 30, 2005·Journal of Ethnopharmacology·Hyun-Tai LeeChang-Koo Shim
Jun 24, 2008·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·S Engdal, O G Nilsen
Oct 17, 2008·The New England Journal of Medicine·Peter J Kahrilas

❮ Previous
Next ❯

Citations

Oct 23, 2012·BMC Complementary and Alternative Medicine·Vijayapandi PandyZahurin Mohamed
Jan 20, 2016·International Journal of Biological Macromolecules·Dyély C O CamposHermógenes D Oliveira
Sep 26, 2015·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Pratibha V NerurkarErik Saksa
Jan 24, 2018·Critical Reviews in Food Science and Nutrition·Sui Kiat ChangFereidoon Shahidi

❮ Previous
Next ❯

Related Concepts

Related Feeds

Atrial Fibrillation

Atrial fibrillation is a common arrhythmia that is associated with substantial morbidity and mortality, particularly due to stroke and thromboembolism. Here is the latest research.

Addiction

This feed focuses mechanisms underlying addiction and addictive behaviour including heroin and opium dependence, alcohol intoxication, gambling, and tobacco addiction.

Arrhythmia

Arrhythmias are abnormalities in heart rhythms, which can be either too fast or too slow. They can result from abnormalities of the initiation of an impulse or impulse conduction or a combination of both. Here is the latest research on arrhythmias.