GastroPanel: evaluation of the usefulness in the diagnosis of gastro-duodenal mucosal alterations in children

Clinica Chimica Acta; International Journal of Clinical Chemistry
Graziella GuarisoMario Plebani

Abstract

The combined evaluation of serum pepsinogens A (PGA) and C (PGC), gastrin-17 (G17) and anti-H. pylori antibodies (anti-H. pylori)(GastroPanel) has recently been proposed as a useful aid for investigating H. pylori-associated gastric mucosal inflammation. Our aim was to evaluate whether GastroPanel can correctly classify children who need or not endoscopy (EGD). GastroPanel was performed in 554 consecutive children subjected to EGD. PGC and anti-H. pylori were sensitive (82.5% and 73.1%) and specific (58.1% and 84.0%) indices of H. pylori infection. Antral H. pylori colonization density, inflammation and activity grades were correlated with PGC. PGC and G17 were significantly higher in children with celiac disease (14.9+/-0.88 microg/L and 5.6+/-0.79 pmol/L) than in controls (8.5+/-0.38 microg/L and 2.4+/-0.24 pmol/L). The best cut-offs to distinguish H. pylori infected children from controls were 7.45 microg/L for PGC, 4.2 pmol/L for G17, 18 U for anti-H. pylori and 25 microg/L for PGA. With these cut-offs, GastroPanel had a NPV of 89.6% and a PPV of 66.8%. A negative GastroPanel result in children with upper abdominal non alarm symptoms, should allow the paediatrician to reasonably rule out the presence of major gastro-duodena...Continue Reading

References

Jan 1, 1993·Critical Reviews in Clinical Laboratory Sciences·M Plebani
Jul 11, 1998·Journal of Clinical Pathology·K M FeeleyC F McCarthy
Feb 17, 2000·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·I GrittiG S Roi
Oct 11, 2001·Journal of Pediatric Gastroenterology and Nutrition·K P FitzpatrickC Macarthur
May 7, 2002·Clinical Medicine : Journal of the Royal College of Physicians of London·Barry Marshall
Jan 22, 2004·Journal of Pediatric Gastroenterology and Nutrition·Margherita BonamicoFabio Massimo Magliocca
Feb 3, 2004·The Journal of Clinical Investigation·Martin J Blaser, John C Atherton
Sep 15, 2004·European Journal of Pharmacology·Peter C KonturekWladyslaw Ochmański
Oct 14, 2004·Pflügers Archiv : European journal of physiology·Graham DockrayAndrea Varro
Nov 10, 2004·Best Practice & Research. Clinical Endocrinology & Metabolism·Graham J Dockray
Dec 2, 2004·Journal of Pediatric Gastroenterology and Nutrition·Giuseppina OderdaGianni Bona
Dec 2, 2004·Journal of Pediatric Gastroenterology and Nutrition·Nicolas KalachJosette Raymond
Mar 1, 2005·Journal of Pediatric Gastroenterology and Nutrition·Carlo Di LorenzoUNKNOWN NASPGHAN Committee on Chronic Abdominal Pain
Jun 25, 2005·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·B GermanáA Franzé
May 9, 2006·Gastroenterology·Andrée RasquinLynn S Walker
Jun 22, 2006·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·A D HopperD S Sanders
Sep 5, 2006·Diagnostic Microbiology and Infectious Disease·Antti I KoivusaloKaija-Leena Kolho
Dec 5, 2006·Gut·Massimo RuggeDavid Y Graham
Feb 27, 2007·Current Problems in Pediatric and Adolescent Health Care·M Luisa Mearin
Sep 11, 2007·Digestive Diseases·Gian Luigi de AngelisFrancesco Di Mario

❮ Previous
Next ❯

Citations

Feb 10, 2011·Journal of Gastroenterology and Hepatology·Cai-yun HeYuan Yuan
Aug 18, 2012·ISRN Gastroenterology·M GasparettoG Guariso
Nov 26, 2010·Helicobacter·Xavier CalvetFrancis Mégraud
Sep 5, 2015·Gastroenterology Research and Practice·Yuehua GongYuan Yuan
Jun 19, 2013·Nature Reviews. Gastroenterology & Hepatology·William L NeumannRobert M Genta
Aug 27, 2014·Scandinavian Journal of Gastroenterology·Liping SunYuan Yuan
Mar 3, 2020·Frontiers in Microbiology·Sergio GeorgeMiguel O'Ryan
Jul 7, 2017·European Journal of Pediatrics·Eias KassemKhitam Muhsen
Jul 15, 2018·American Journal of Clinical Pathology·Marcello BagnascoNicola Bizzaro
Dec 6, 2020·International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases·Yalda LuceroMiguel O'Ryan

❮ Previous
Next ❯

Related Concepts

Related Feeds

Atrophic Gastritis

Atrophic Gastritis is a process where gastric glandular cells are lost and replaced with firbous tissues, as a result of chronic inflammation. Learn more about Atrophic Gastritis here.