PMID: 11902806Mar 21, 2002Paper

Gastroprotective activity of solidagenone on experimentally-induced gastric lesions in rats

The Journal of Pharmacy and Pharmacology
Jaime A RodríguezGuillermo Schmeda-Hirschmann

Abstract

The gastroprotective effect of the labdane diterpene solidagenone was assessed on gastric ulcer in rats. The effect of a single oral dose of the compound was evaluated at 50, 100 and 200 mg kg(-1) in the following test systems: pylorus ligature (Shay), aspirin- and ethanol-induced gastric ulcers. In pylorus-ligated rats (Shay model), the ulcerative index decreased by 37% with solidagenone pre-treatment at the three assayed doses. The effect of a single oral dose of 50 mg kg(-1) solidagenone was comparable with ranitidine at the same concentration and similar to higher doses of the compound. A significant effect (P < 0.001) at 100 and 200 mg kg(-1) was observed in the aspirin-induced ulcer model. At both doses, reduction in the number of lesions was approximately 50% compared with controls. The effect was comparable with the reference compound ranitidine (50 mg kg(-1)). With the ethanol-induced gastric ulcers, the effect of solidagenone at 100 and 200 mg kg(-1) was similar to a single oral dose of 20 mg kg(-1) omeprazole with a 50% reduction of the mean number of lesions compared with controls. In acute toxicity tests on mice, intraperitoneal administration of solidagenone showed no toxicity at doses up to 600 mg kg(-1). This is...Continue Reading

References

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Citations

May 22, 2002·Journal of Ethnopharmacology·Guillermo Schmeda-HirschmannLuis Astudillo
Jul 16, 2003·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Jaime A RodríguezGuillermo Schmeda-Hirschmann
Feb 22, 2005·The Journal of Pharmacy and Pharmacology·Jaime A RodríguezGuillermo Schmeda-Hirschmann
Jul 5, 2005·Journal of Ethnopharmacology·Guillermo Schmeda-Hirschmann, Erdem Yesilada
Jun 30, 2005·Journal of Ethnopharmacology·Guillermo Schmeda-HirschmannTania Yáñez
Oct 23, 2010·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Guillermo Schmeda-HirschmannCristina Theoduloz
Dec 26, 2018·Human & Experimental Toxicology·H M HafezN M Zenhom
Aug 12, 2020·Basic & Clinical Pharmacology & Toxicology·Simone S ValverdeOrlando V de Sousa
Mar 26, 2021·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·Bruna Taciane da Silva BortoletiWander Rogério Pavanelli
Oct 12, 2021·Basic & Clinical Pharmacology & Toxicology·Juliana Fraga VasconcelosMilena Botelho Pereira Soares

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