Gastroprotective effect of diligustilide isolated from roots of Ligusticum porteri coulter & rose (Apiaceae) on ethanol-induced lesions in rats

Journal of Ethnopharmacology
Josué A Velázquez-MoyadoAndrés Navarrete

Abstract

The rhizome of Ligusticum porteri Coulter& Rose (LP) has been traditionally used by the ethnic group Raramuri in the North of México for treatment of diabetes, tuberculosis, stomachaches, diarrhea and ritual healing ceremonies. It is use as antiulcer remedy has been extended to all Mexico. To evaluate the gastroprotective activity of LP organic extracts and the major natural product diligustilide (DLG),using as experimental model the inhibition of the ethanol-induced lesions in rats. Gastric ulcers were induced by intragastric instillation of absolute ethanol (1 mL). We tested the gastroprotective activity of the organic extracts of LP and the pure compound DLG. The ulcer index (UI) was determined to measure the activity. In order to elucidate the action mechanism of DLG the animals were treated with L-NAME, N-ethylmalemide, Forskolin, 2',5'-dideoxyadenosine, Indomethacin, Glibenclameide, Diazoxide, NaHS and DL-Propargylglycine. The pylorus-ligated rat model was used to measure gastric secretion. The oral administration of organic extracts of Ligusticum porteri showed gastroprotective effect at 30 mg/Kg on ethanol induced gastric lesions; hexane and dichloromethane extracts were the most active. DLG was the major compound in th...Continue Reading

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Citations

Sep 8, 2017·Inflammopharmacology·Josué Arturo Velázquez-MoyadoAndrés Navarrete
Apr 9, 2019·Drug Development Research·Elizabeth A Pineda-PeñaAndrés Navarrete Castro
Jul 25, 2019·Natural Product Research·Alejandra Orona-OrtizAndrés Navarrete
Dec 28, 2019·Mini Reviews in Medicinal Chemistry·Hamidreza ArdalaniAmirhossein Sahebkar
Apr 4, 2020·Naunyn-Schmiedeberg's Archives of Pharmacology·Elizabeth Arlen Pineda-PeñaAndrés Navarrete
Oct 10, 2020·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Xiaodan QuXueshi Huang

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