Gastroprotective effect of kefir on ulcer induced in irradiated rats

Journal of Photochemistry and Photobiology. B, Biology
Hanan A Fahmy, Amel F M Ismail

Abstract

The current study was designed to investigate the protective effect of kefir milk on ethanol-induced gastric ulcers in γ-irradiated rats. The results of the present study revealed that treatment with γ-irradiation and/or ethanol showed a significant increase in ulcers number, total acidity, peptic, H(+)K(+)ATPase, MMP-2 and MMP-9 activities and MDA level, which were accompanied by a significant decrease in the mucus content, the stomach GSH level, the GSH-Px activity and DNA damage. Pre-treatment with kefir milk exert significant improvement in all the tested parameters. Kefir milk exerts comparable effect to that of the antiulcer drug ranitidine. In conclusion, the present study revealed that oral administration of kefir milk prevents ethanol-induced gastric ulcer in γ-irradiated rats that could attribute to its antioxidant, anti-apoptotic and radio-protective activities.

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Citations

Nov 14, 2016·Journal of Photochemistry and Photobiology. B, Biology·Nashwa H ZaherAmel F M Ismail
Feb 23, 2017·Nutrition Research Reviews·Damiana D RosaMaria do Carmo G Peluzio
Dec 8, 2017·Journal of Medicinal Food·Wilman CarrilloJoão Ernesto de Carvalho
Feb 27, 2018·Journal of Dairy Science·Jeong-Hyun YooHae-Jeung Lee
Dec 30, 2017·Probiotics and Antimicrobial Proteins·Meire Dos Santos Falcão de LimaMaria Taciana Holanda Cavalcanti
Jun 27, 2020·Environmental Science and Pollution Research International·Ola Sayed M AliOmnia Abd El-Rahman
Nov 7, 2020·Critical Reviews in Food Science and Nutrition·Mariana Buranelo EgeaAilton Cesar Lemes

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