Gastroretentive drug delivery systems

Expert Opinion on Drug Delivery
Alexander StreubelRoland Bodmeier

Abstract

A controlled drug delivery system with prolonged residence time in the stomach is of particular interest for drugs that i) are locally active in the stomach, ii) have an absorption window in the stomach or in the upper small intestine, iii) are unstable in the intestinal or colonic environment, or iv) exhibit low solubility at high pH values. This article gives an overview of the parameters affecting gastric emptying in humans as well as on the main concepts used to design pharmaceutical dosage forms with prolonged gastric residence times. In particular, bioadhesive, size-increasing and floating drug delivery systems are presented and their major advantages and shortcomings are discussed. Both single- and multiple-unit dosage forms are reviewed and, if available, results from in vivo trials are reported.

References

Feb 1, 1992·Journal of Pharmaceutical Sciences·Y KawashimaY Itoh
Aug 1, 1990·Pharmaceutical Research·W S Shalaby, K Park
Jan 1, 1987·The Journal of Pharmacy and Pharmacology·R Khosla, S S Davis
Mar 1, 1966·Journal of Pharmaceutical Sciences·G Levy, W J Jusko
Jan 1, 1993·The Journal of Pharmacy and Pharmacology·B C ThanooA Jayakrishnan
Feb 1, 1994·Journal of Pharmaceutical Sciences·A MenonA Sakr
Sep 1, 1993·Pharmaceutical Research·S Desai, S Bolton
Aug 1, 1996·Biomaterials·N A Peppas, J J Sahlin
Jun 1, 1997·Pharmaceutical Research·A A DeshpandeW Malick
Jan 7, 1999·Drug Development and Industrial Pharmacy·G L Chen, W H Hao
Jan 23, 1999·Journal of Controlled Release : Official Journal of the Controlled Release Society·L YangR Fassihi
Mar 4, 1999·Journal of Controlled Release : Official Journal of the Controlled Release Society·F KedzierewiczP Maincent
Jul 9, 1999·Journal of Biomedical Materials Research·J ChenK Park
Sep 2, 1999·Journal of Controlled Release : Official Journal of the Controlled Release Society·I Krögel, R Bodmeier
Sep 30, 1999·International Journal of Pharmaceutics·I Krögel, R Bodmeier
Nov 27, 1999·Journal of Microencapsulation·J H LeeH K Choi
Dec 22, 1999·Journal of Controlled Release : Official Journal of the Controlled Release Society·B N Singh, K H Kim
Jan 21, 2000·Journal of Controlled Release : Official Journal of the Controlled Release Society·J ChenK Park
Feb 17, 2000·International Journal of Pharmaceutics·S BaumgartnerB Zorko
Mar 4, 2000·Journal of Controlled Release : Official Journal of the Controlled Release Society·J Chen, K Park
Apr 18, 2000·International Journal of Pharmaceutics·E BulgarelliM T Bernabei
May 29, 2000·Drug Development and Industrial Pharmacy·V IannuccelliM T Bernabei
Jun 22, 2000·Journal of Pharmaceutical Sciences·J W LeeJ R Robinson
Jul 29, 2000·Drug Development and Industrial Pharmacy·A K SinglaA Singh
Jul 29, 2000·Drug Development and Industrial Pharmacy·A O Nur, J S Zhang
Sep 23, 2000·International Journal of Pharmaceutics·S J JacksonA C Perkins
Feb 13, 2001·International Journal of Pharmaceutics·L WhiteheadJ T Fell
May 10, 2001·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·M CuñaD Torres
May 30, 2001·International Journal of Pharmaceutics·A H El-KamelV F Naggar
Aug 10, 2001·Drug Metabolism Reviews·K S SoppimathT M Aminabhavi

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Citations

May 18, 2013·International Journal of Pharmaceutics·Lifang YinQiang Zhang
Jan 30, 2014·International Journal of Pharmaceutics·Sally A El-ZahabyAmal H El-Kamel
Jan 17, 2009·AAPS PharmSciTech·Ravichandran MahalingamXiaoling Li
Nov 11, 2009·AAPS PharmSciTech·Karunakar NeelamBhaskara R Jasti
Jun 2, 2009·Chemical & Pharmaceutical Bulletin·Rajeev Garg, Ghanshyam Das Gupta
Jun 5, 2010·Chemical & Pharmaceutical Bulletin·Surendra Ganeshlal GattaniVeena Shailendra Belgamwar
Apr 8, 2014·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Veronika A EberleMaxim Puchkov
Apr 5, 2014·Journal of Microencapsulation·Ankit Anand Kharia, Akhlesh Kumar Singhai
May 9, 2007·Pharmaceutical Development and Technology·Kenneth C Waterman
Jun 6, 2008·Expert Opinion on Drug Delivery·Leonid Kagan, Amnon Hoffman
Aug 27, 2015·Drug Development and Industrial Pharmacy·Veronika A EberleMaxim Puchkov
Mar 27, 2012·Expert Opinion on Drug Delivery·Rakesh PahwaKanchan Kohli
Aug 30, 2008·Expert Opinion on Drug Delivery·Dhaivat C Parikh, Avani F Amin
Jul 7, 2015·Drug Development and Industrial Pharmacy·Navjot KanwarV R Sinha
Dec 4, 2010·Drug Development and Industrial Pharmacy·Katharina LeithnerAndreas Bernkop-Schnürch
Sep 5, 2013·Drug Development and Industrial Pharmacy·Lulu MaJianming Chen
Jun 16, 2011·Expert Opinion on Drug Delivery·Pascal PrinderreClaus Fuxen
Nov 26, 2009·Journal of Pharmaceutical Sciences·K AlbrechtA Bernkop-Schnürch
Nov 12, 2009·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Ray-Neng ChenMing-Thau Sheu
May 26, 2009·International Journal of Pharmaceutics·C SauzetP Prinderre
Dec 9, 2015·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Anh Q VoMichael A Repka
Feb 16, 2008·International Journal of Pharmaceutics·Sun Woo JangKang Choon Lee
Feb 6, 2008·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Sandra StrübingKarsten Mäder
Dec 11, 2007·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Leonid Kagan, Amnon Hoffman
Apr 18, 2009·British Journal of Clinical Pharmacology·Morten A KarsdalClaus Christiansen
Nov 20, 2014·British Journal of Clinical Pharmacology·Morten Asser KarsdalKim Henriksen
Feb 12, 2014·Drug Delivery·Mahasen A RadwanDalia A El-Maraghy
Sep 21, 2010·Pharmaceutical Development and Technology·Subhash S VaghaniRohit Borda
May 23, 2015·Journal of Aquatic Animal Health·Kun HuXian-Le Yang
Dec 27, 2011·Journal of Controlled Release : Official Journal of the Controlled Release Society·Yuanyuan Ji, Yulin Deng
Apr 5, 2014·International Journal of Biological Macromolecules·Prashant UpadhyayArun Kumar Wahi

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