Gastrostomy in patients with prion disease

Prion
Y IwasakiM Yoshida

Abstract

Patients with prion diseases can live for long periods of time in a state of akinetic mutism given appropriate management of their symptoms. To study symptom support in these cases, we performed gastrostomies on 3 patients with V180I genetic Creutzfeldt-Jakob disease (CJD) who had become akinetic and mute, and compared them to 14 other similar patients being fed by tube. In the 3 gastrostomy cases, there were no direct complications due to the gastrostomy or tube feeding, nor were there episodes of discontinuation of tube feeding or initiation of continuous drip infusion due to severe complications. Antibiotics were administered for mild infections, a complication of CJD, with 0.2% and 8.8% of the total time after gastrostomy being used for intravenous or transluminal administration, respectively. We compared the present patient series with that of our previous report statistically, and found that patients undergoing gastrostomy required significantly fewer discontinuations of tube feeding than those who did not. No significant difference in antibiotic administration was found between groups, however. It is our conclusion that gastrostomy should be allowed for symptom support in akinetic patients with prion disease, but adequat...Continue Reading

References

Sep 28, 2005·Human Genetics·Gábor G KovácsUNKNOWN EUROCJD
Aug 21, 2010·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·Y IwasakiY Hashizume
Sep 22, 2010·Brain : a Journal of Neurology·Ichiro NozakiMasahito Yamada
Jan 29, 2011·Neuropathology : Official Journal of the Japanese Society of Neuropathology·Yasushi IwasakiYoshio Hashizume
Jun 13, 2012·Rinshō shinkeigaku = Clinical neurology·Yasushi IwasakiMasumi Ito
Jul 6, 2015·Journal of the Neurological Sciences·Yasushi IwasakiMari Yoshida
Oct 27, 2015·EBioMedicine·Arthur J L Cooper

❮ Previous
Next ❯

Citations

May 6, 2020·Neuropathology : Official Journal of the Japanese Society of Neuropathology·Akio AkagiMari Yoshida
Jan 1, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Katsuya SatohNoriyuki Nishida

❮ Previous
Next ❯

Software Mentioned

Excel
Statcel

Related Concepts

Related Feeds

Antifungals (ASM)

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.

Antifungals

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.

Bovine Spongiform Encephalopathy

Bovine spongiform encephalopathy is a neurodegenerative disease belonging to the transmissible spongiform encephalopathies, a group of diseases including sheep scrapie and human Creutzfeldt-Jakob disease. Here is the latest research.

Bovine Spongiform Encephalopathy (MDS)

Bovine spongiform encephalopathy is a neurodegenerative disease belonging to the transmissible spongiform encephalopathies, a group of diseases including sheep scrapie and human Creutzfeldt-Jakob disease. Here is the latest research.