GATA-3 directly remodels the IL-10 locus independently of IL-4 in CD4+ T cells

The Journal of Immunology : Official Journal of the American Association of Immunologists
John ShoemakerA O'Garra

Abstract

IL-10 is a major regulator in inflammatory responses. Although various transcription factors were defined to enhance IL-10, the molecular mechanism for the initiation of Il-10 transcription, remains unknown. mRNA profiling of six distinct primary CD4+ T cell populations showed differential expression of the transcription factor GATA-3 correlated with levels of IL-10 expression. We showed that ectopic expression of GATA-3 in naive primary CD4+ T cells enhanced expression of IL-10 by these cells and uncovered a possible mechanism for this effect. We found that GATA-3 induced changes of the chromatin structure at the Il-10 locus and that these changes occur even in the absence of IL-4. Furthermore we found that in the presence of GATA-3 the histones at the Il-10 locus become acetylated. Despite being recruited in vivo to two locations on the Il-10 locus, GATA-3 did not transactivate the IL-10 promoter. We therefore suggest a key role of GATA-3 in instructing Il-10 gene expression in primary CD4+ T cells, possibly by switching and stabilizing the Il-10 locus into a transcriptionally competent status.

References

Nov 1, 1991·Science·R KühnW Müller
Dec 1, 1989·The Journal of Experimental Medicine·D F FiorentinoT R Mosmann
May 5, 1999·Clinical Immunology : the Official Journal of the Clinical Immunology Society·I A FerberA O'Garra
Feb 5, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·H D BrightbillS T Smale
Jun 22, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·M ToneH Waldmann
Mar 13, 2001·Annual Review of Immunology·K W MooreA O'Garra
May 22, 2001·British Medical Bulletin·D S Robinson
Jul 7, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·M C NawijnR W Hendriks
Oct 10, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·H KishikawaI C Ho
Oct 10, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·S RaoM F Shannon
Jan 4, 2003·Nature Reviews. Immunology·Antonio Alcami
Jan 11, 2003·Science·Shohei HoriShimon Sakaguchi
Mar 4, 2003·Nature Immunology·Jason D FontenotAlexander Y Rudensky
Mar 4, 2003·Nature Immunology·Roli KhattriFred Ramsdell
Jun 21, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·Löms Ziegler-HeitbrockElke Benkhart
Jul 9, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·Yi-Wen LiuWen-Chang Chang
Feb 11, 2004·Proceedings of the National Academy of Sciences of the United States of America·Sung-Yun PaiI-Cheng Ho
May 7, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Pedro L VieiraAnne O'Garra
May 12, 2004·Advances in Immunology·Anne O'Garra, Douglas Robinson
Jul 31, 2004·Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire·Lin LiJames R Davie
Aug 21, 2004·The Journal of Biological Chemistry·Sin-Hyeog ImAnjana Rao
Oct 8, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Leon SuJoerg Ermann
Oct 12, 2004·Nature Immunology·Jinfang ZhuWilliam E Paul
Feb 9, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Zheng-Yu WangAlexander L Dent
Feb 25, 2005·The Journal of Experimental Medicine·Roland GrenninglohI-Cheng Ho
Mar 8, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Shanjin CaoXiaojing Ma
Jul 9, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Margarida SaraivaAnne O'Garra
Nov 23, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Elizabeth A Jones, Richard A Flavell

❮ Previous
Next ❯

Citations

Nov 13, 2007·Nature Immunology·Jason S StumhoferChristopher A Hunter
Jun 21, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·Alessandro SerraAndreas Wack
Jun 17, 2008·Tissue Antigens·N van PanhuysM J McConnell
Feb 16, 2010·Nature Reviews. Immunology·Margarida Saraiva, Anne O'Garra
Jan 21, 2010·Immunologic Research·Christian M Hedrich, Jay H Bream
Sep 23, 2014·The Journal of Immunology : Official Journal of the American Association of Immunologists·Joel V Weinstock, David E Elliott
Dec 31, 2014·The Journal of Immunology : Official Journal of the American Association of Immunologists·Ryo HatanoChikao Morimoto
Jul 7, 2015·Journal of Immunology Research·Wook-Jin Chae, Alfred L M Bothwell
Dec 16, 2016·Parasite Immunology·D E Elliott, J V Weinstock
Jan 20, 2017·The Journal of Immunology : Official Journal of the American Association of Immunologists·Byunghee KohMark H Kaplan
Jun 6, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Susana RoqueMargarida Correia-Neves
Jan 5, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Ziyan YangXia Zhang
Oct 1, 2008·European Journal of Immunology·Maria H LexbergHyun-Dong Chang
Apr 11, 2008·Genes and Immunity·L R GrantJ H Bream
Jan 24, 2009·Immunological Reviews·Craig L Maynard, Casey T Weaver
Jan 24, 2012·The Journal of Immunology : Official Journal of the American Association of Immunologists·Choong-Gu LeeSin-Hyeog Im
Jul 14, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·Ayele-Nati N AhyiMark H Kaplan
May 18, 2011·Infection and Immunity·Joshua C Cyktor, Joanne Turner
Sep 24, 2011·Nature Reviews. Immunology·Ruslan MedzhitovAnne O'Garra
May 2, 2012·The Journal of Immunology : Official Journal of the American Association of Immunologists·John A AltinMatthew C Cook
Mar 21, 2012·Scandinavian Journal of Immunology·H Bouabe
Apr 15, 2015·The Journal of Immunology : Official Journal of the American Association of Immunologists·Jonathan M HanMegan K Levings
Jun 8, 2014·The Journal of Immunology : Official Journal of the American Association of Immunologists·Margarite L TarrioChristine A Biron
Jul 16, 2013·The Journal of Immunology : Official Journal of the American Association of Immunologists·Long HangJoel V Weinstock
Mar 2, 2013·The Journal of Biological Chemistry·Vemika ChandraPawan Gupta
Aug 6, 2014·European Journal of Immunology·Alice MayerFabienne Andris
Feb 3, 2016·Frontiers in Microbiology·Phillip D FrommHeinrich Körner
Mar 10, 2019·The Journal of Immunology : Official Journal of the American Association of Immunologists·Long HangJoel V Weinstock
May 9, 2007·The Journal of Experimental Medicine·Ian R HumphreysCarl F Ware
Aug 23, 2007·Nature Immunology·Paulo Vieira, Anne O'Garra
Sep 16, 2008·European Journal of Immunology·Jan Piet van HamburgRudi W Hendriks
Oct 16, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·Sarah E Umetsu, Susan Winandy
Feb 14, 2007·The Journal of Experimental Medicine·Giorgio Trinchieri
Jul 2, 2009·Yonsei Medical Journal·Choong-Gu LeeSin-Hyeog Im
Jul 5, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Xia ZhangDavid M Mosser
Apr 22, 2011·Journal of Cellular and Molecular Medicine·Swati PatelShubhada Chiplunkar
Dec 19, 2015·Clinical & Translational Immunology·Anusree Mahanta, Shashi Baruah
May 22, 2016·The Journal of Immunology : Official Journal of the American Association of Immunologists·Anne O'Garra, Leona Gabryšová
Mar 19, 2014·Cell Biochemistry and Biophysics·Guo TianDian Zhou

❮ Previous
Next ❯

Related Concepts

Related Feeds

Bioinformatics in Biomedicine

Bioinformatics in biomedicine incorporates computer science, biology, chemistry, medicine, mathematics and statistics. Discover the latest research on bioinformatics in biomedicine here.

Ataxia telangiectasia (MDS)

Ataxia telangiectasia is a rare neurodegenerative diseases caused by defects in the ATM gene, which is involved in DNA damage recognition and repair pathways. Here is the latest research on this autosomal recessive disease.

Allergy and Asthma

Allergy and asthma are inflammatory disorders that are triggered by the activation of an allergen-specific regulatory t cell. These t cells become activated when allergens are recognized by allergen-presenting cells. Here is the latest research on allergy and asthma.

Related Papers

The Journal of Immunology : Official Journal of the American Association of Immunologists
Sarah E Umetsu, Susan Winandy
The Journal of Immunology : Official Journal of the American Association of Immunologists
Saritha KusamAlexander L Dent
© 2021 Meta ULC. All rights reserved