GATA-binding protein-3 regulates T helper type 2 cytokine and ifng loci through interaction with metastasis-associated protein 2.

Immunology
Soo Seok HwangG R Lee

Abstract

GATA-binding protein-3 (GATA-3) regulates the T helper type 2 (Th2) cytokine locus through induction of chromatin remodelling. However, the molecular mechanism for this is poorly understood. To understand this mechanism better, we screened GATA-3 interacting proteins using affinity purification and mass spectrometry. We found that GATA-3 bound to metastasis-associated protein 2 (MTA-2), a component of the NuRD chromatin remodelling complex. GATA-3 and MTA-2 in turn bound to several regulatory regions of the Th2 cytokine locus and the ifng promoter. Cell transfection assay showed that MTA-2 acted as an antagonist with GATA-3 in the expression of Th2 cytokines, but co-operated with GATA-3 in the repression of the ifng gene expression. These results suggest that GATA-3 interacts with MTA-2 to co-ordinately regulate Th2 cytokine and ifng loci during T helper cell differentiation.

References

Oct 31, 1996·Nature·A K AbbasA Sher
Jan 4, 2001·Current Opinion in Hematology·C Dong, R A Flavell
Nov 21, 2001·The Journal of Experimental Medicine·M ZhouK M Murphy
Jul 2, 2003·Molecular and Cellular Biology·Marcin RylskiMitchell J Weiss
Jul 23, 2003·Immunity·Gap Ryol LeeRichard A Flavell
Feb 11, 2004·Proceedings of the National Academy of Sciences of the United States of America·Sung-Yun PaiI-Cheng Ho
Sep 21, 2004·Nature Immunology·Charalampos G Spilianakis, Richard A Flavell
Oct 12, 2004·Nature Immunology·Jinfang ZhuWilliam E Paul
Jan 22, 2005·Science·Eun Sook HwangLaurie H Glimcher
Jun 21, 2005·Immunity·Hua-Chen ChangMark H Kaplan
Mar 23, 2006·Annual Review of Immunology·K Mark AnselAnjana Rao
Apr 19, 2006·Immunity·Gap Ryol LeeRichard A Flavell
Jan 5, 2007·Annual Review of Immunology·Casey T WeaverLaurie E Harrington
Apr 17, 2007·Current Opinion in Immunology·Brigitta Stockinger, Marc Veldhoen
Dec 7, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Xinyan ZhaoWei-ping Zeng
Jan 5, 2008·Nuclear Receptor Signaling·Bramanandam ManavathiRakesh Kumar

❮ Previous
Next ❯

Citations

Jul 10, 2012·Biochemical and Biophysical Research Communications·Soo Seok HwangGap Ryol Lee
Sep 7, 2012·The Journal of Investigative Dermatology·Heather M GibsonHenry K Wong
Apr 30, 2016·Biochimica Et Biophysica Acta·Soo Seok HwangRichard A Flavell

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.