GATA factor-dependent regulation of cardiac m2 muscarinic acetylcholine gene transcription.

The Journal of Biological Chemistry
M L Rosoff, N M Nathanson

Abstract

The m2 subtype is the predominant muscarinic acetylcholine receptor subtype expressed in heart and regulates the rate and force of cardiac contraction. We have previously reported the isolation of the promoter region for the chick m2 receptor gene and defined a region of the chick m2 promoter sufficient for high level expression in cardiac primary cultures. In this manuscript we demonstrate transactivation of cm2 promoter by the GATA family of transcription factors. In addition, we define the GATA-responsive element in the chick m2 promoter and demonstrate that this element is required for expression in cardiac primary cultures. Finally, we demonstrate specific binding of both a chick heart nuclear protein and of cloned chick GATA-4, -5, and -6 to the GATA-responsive element.

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Citations

Nov 15, 2002·Journal of Biomedical Science·R Bonfante-CabarcasJ A Moreno-Yanes
Mar 9, 1999·Life Sciences·D SaffenT Haga
Sep 18, 2001·Canadian Journal of Physiology and Pharmacology·K McBride, M Nemer
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May 18, 1999·Molecular and Cellular Biology·F CharronM Nemer

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